Literature DB >> 7495372

Inhibitory effect of methylmercury on migration and tube formation by cultured human vascular endothelial cells.

T Kishimoto1, T Oguri, M Abe, H Kajitani, M Tada.   

Abstract

The effect of methylmercury chloride (MeHg) on migration and tube formation by cultured human umbilical vein endothelial cells (HUVECs) was quantitatively analyzed. The distance of endothelial cell outgrowth from the scraped edge of a monolayer was measured. HUVEC outgrowth was inhibited by MeHg (1.0-5.0 microM) treatment in a dose-dependent manner. Tube formation was studied by culturing the cells on gelled basement membrane matrix (Matrigel). Treatment of HUVECs with 0.1-5.0 microM MeHg for 24 h inhibited tube formation dose-dependently. These results suggest that migration and tube formation by HUVECs are susceptible to MeHg cytotoxicity, and that MeHg could be injurious to endothelial cell function, which may be involved in the pathogenesis of arteriosclerosis.

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Year:  1995        PMID： 7495372     DOI： 10.1007/s002040050184

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  18 in total

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Authors:  J A Geelen; J A Dormans; A Verhoef
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

2.  Focal cerebellar and cerebellar atrophy in a human subject due to organic mercury compounds.

Authors:  D HUNTER; D S RUSSELL
Journal:  J Neurol Neurosurg Psychiatry       Date:  1954-11       Impact factor: 10.154

3.  Toward an understanding of angiogenesis: search and discovery.

Authors:  J Folkman
Journal:  Perspect Biol Med       Date:  1985       Impact factor: 1.416

4.  The auditory system in methyl mercurial intoxication: a neuropathological investigation on 14 autopsy cases in Niigata, Japan.

Authors:  K Oyanagi; E Ohama; F Ikuta
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

5.  Endothelial regeneration. III. Time course of intimal changes after small defined injury to rat aortic endothelium.

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Journal:  Lab Invest       Date:  1981-04       Impact factor: 5.662

6.  Injury-induced release of basic fibroblast growth factor from bovine aortic endothelium.

Authors:  C M Gajdusek; S Carbon
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7.  High potassium diets protect against dysfunction of endothelial cells in stroke-prone spontaneously hypertensive rats.

Authors:  T Sugimoto; L Tobian; M C Ganguli
Journal:  Hypertension       Date:  1988-06       Impact factor: 10.190

8.  Narrow superficial injury to rabbit aortic endothelium. The healing process as observed by scanning electron microscopy.

Authors:  M M Ramsay; L N Walker; D E Bowyer
Journal:  Atherosclerosis       Date:  1982-06       Impact factor: 5.162

9.  Protein kinase C regulates endothelial cell tube formation on basement membrane matrix, Matrigel.

Authors:  J L Kinsella; D S Grant; B S Weeks; H K Kleinman
Journal:  Exp Cell Res       Date:  1992-03       Impact factor: 3.905

10.  Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.

Authors:  T F Lüscher; P M Vanhoutte
Journal:  Hypertension       Date:  1986-04       Impact factor: 10.190
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  7 in total

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Authors:  Mark C Houston
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Journal:  Environ Health Perspect       Date:  2011-01-10       Impact factor: 9.031

4.  Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis.

Authors:  Shaohua Wang; Bin Zheng; Hongye Zhao; Yongjun Li; Xinhua Zhang; Jinkun Wen
Journal:  Int J Mol Med       Date:  2021-02-04       Impact factor: 4.101

5.  Toxic effects of chronic mercury exposure on the retinal nerve fiber layer and macular and choroidal thickness in industrial mercury battery workers.

Authors:  Metin Ekinci; Erdinç Ceylan; Sadullah Keleş; Halil Hüseyin Cağatay; Aytekin Apil; Burak Tanyıldız; Gunay Uludag
Journal:  Med Sci Monit       Date:  2014-07-24

6.  MARCKS is involved in methylmercury-induced decrease in cell viability and nitric oxide production in EA.hy926 cells.

Authors:  Cuong VAN Dao; Md Zahorul Islam; Kasumi Sudo; Mitsuya Shiraishi; Atsushi Miyamoto
Journal:  J Vet Med Sci       Date:  2016-06-24       Impact factor: 1.267

Review 7.  Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies.

Authors:  Jayant Patwa; Swaran Jeet Singh Flora
Journal:  Int J Mol Sci       Date:  2020-05-29       Impact factor: 5.923
  7 in total

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