OBJECTIVE: To evaluate the relationship between high serum levels of IgE and the release of interleukin-4 (IL-4) from cultured lymphocytes of a patient with adult onset Still's disease. METHODS: IL-4 concentrations in plasma and culture from inactivated peripheral blood mononuclear cells were assessed by enzyme immunoassay during febrile episodes and remission. RESULTS: A high level of IL-4 was detected by enzyme immunoassay in the peripheral blood mononuclear cells cultured from the patient. These seemed to correspond with a febrile episode and a high serum IgE concentration. CONCLUSION: Increased serum IgE concentrations during a febrile episode are rare in patients with adult onset Still's disease, but the relationship between the high levels of serum IgE and IL-4 in cultured lymphocytes may provide clues to pathogenesis of the condition.
OBJECTIVE: To evaluate the relationship between high serum levels of IgE and the release of interleukin-4 (IL-4) from cultured lymphocytes of a patient with adult onset Still's disease. METHODS:IL-4 concentrations in plasma and culture from inactivated peripheral blood mononuclear cells were assessed by enzyme immunoassay during febrile episodes and remission. RESULTS: A high level of IL-4 was detected by enzyme immunoassay in the peripheral blood mononuclear cells cultured from the patient. These seemed to correspond with a febrile episode and a high serum IgE concentration. CONCLUSION: Increased serum IgE concentrations during a febrile episode are rare in patients with adult onset Still's disease, but the relationship between the high levels of serum IgE and IL-4 in cultured lymphocytes may provide clues to pathogenesis of the condition.
Authors: M Yamaguchi; A Ohta; T Tsunematsu; R Kasukawa; Y Mizushima; H Kashiwagi; S Kashiwazaki; K Tanimoto; Y Matsumoto; T Ota Journal: J Rheumatol Date: 1992-03 Impact factor: 4.666
Authors: X Paliard; R de Waal Malefijt; H Yssel; D Blanchard; I Chrétien; J Abrams; J de Vries; H Spits Journal: J Immunol Date: 1988-08-01 Impact factor: 5.422
Authors: G Del Prete; E Maggi; P Parronchi; I Chrétien; A Tiri; D Macchia; M Ricci; J Banchereau; J De Vries; S Romagnani Journal: J Immunol Date: 1988-06-15 Impact factor: 5.422
Authors: D Vercelli; H H Jabara; C Cunningham-Rundles; J S Abrams; D B Lewis; J Meyer; L C Schneider; D Y Leung; R S Geha Journal: J Clin Invest Date: 1990-05 Impact factor: 14.808
Authors: J Pouchot; J S Sampalis; F Beaudet; S Carette; F Décary; M Salusinsky-Sternbach; R O Hill; A Gutkowski; M Harth; D Myhal Journal: Medicine (Baltimore) Date: 1991-03 Impact factor: 1.889
Authors: F Rousset; J Robert; M Andary; J P Bonnin; G Souillet; I Chrétien; F Brière; J Pène; J E de Vries Journal: J Allergy Clin Immunol Date: 1991-01 Impact factor: 10.793