Literature DB >> 7494334

Posttranslational signal peptidase cleavage at the flavivirus C-prM junction in vitro.

C E Stocks1, M Lobigs.   

Abstract

We have investigated the cleavages at the flavivirus capsid-prM protein junction in vitro. When expressed in the absence of the flavivirus proteinase, capsid and prM, which are separated by an internal signal sequence, exist as a membrane-spanning precursor protein. Here we show the induction of posttranslational signal peptidase cleavage of prM by trypsin cleavage of a cytoplasmic region of this precursor protein.

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Year:  1995        PMID： 7494334      PMCID： PMC189766     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  In vitro processing of dengue virus type 2 nonstructural proteins NS2A, NS2B, and NS3.

Authors:  F Preugschat; C W Yao; J H Strauss
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

Review 2.  Flavivirus replication strategy.

Authors:  E G Westaway
Journal:  Adv Virus Res       Date:  1987       Impact factor: 9.937

3.  Deletion of the amino-terminal domain of asialoglycoprotein receptor H1 allows cleavage of the internal signal sequence.

Authors:  S R Schmid; M Spiess
Journal:  J Biol Chem       Date:  1988-11-15       Impact factor: 5.157

4.  Partial nucleotide sequence of the Murray Valley encephalitis virus genome. Comparison of the encoded polypeptides with yellow fever virus structural and non-structural proteins.

Authors:  L Dalgarno; D W Trent; J H Strauss; C M Rice
Journal:  J Mol Biol       Date:  1986-02-05       Impact factor: 5.469

5.  Production of yellow fever virus proteins in infected cells: identification of discrete polyprotein species and analysis of cleavage kinetics using region-specific polyclonal antisera.

Authors:  T J Chambers; D W McCourt; C M Rice
Journal:  Virology       Date:  1990-07       Impact factor: 3.616

6.  In vitro processing of dengue virus structural proteins: cleavage of the pre-membrane protein.

Authors:  L Markoff
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

7.  Analyses of the terminal sequences of West Nile virus structural proteins and of the in vitro translation of these proteins allow the proposal of a complete scheme of the proteolytic cleavages involved in their synthesis.

Authors:  T Nowak; P M Färber; G Wengler; G Wengler
Journal:  Virology       Date:  1989-04       Impact factor: 3.616

8.  Formation of the flavivirus envelope: role of the viral NS2B-NS3 protease.

Authors:  V F Yamshchikov; R W Compans
Journal:  J Virol       Date:  1995-04       Impact factor: 5.103

9.  Processing of yellow fever virus polyprotein: role of cellular proteases in maturation of the structural proteins.

Authors:  A Ruiz-Linares; A Cahour; P Després; M Girard; M Bouloy
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

10.  Molecular dissection of the NH2-terminal signal/anchor sequence of rat dipeptidyl peptidase IV.

Authors:  W J Hong; D Doyle
Journal:  J Cell Biol       Date:  1990-08       Impact factor: 10.539
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  18 in total

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Authors:  M P Courageot; M P Frenkiel; C D Dos Santos; V Deubel; P Desprès
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing.

Authors:  S M Amberg; C M Rice
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

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Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

4.  Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles.

Authors:  Beate M Kümmerer; Charles M Rice
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

5.  Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes.

Authors:  Mario Lobigs; Eva Lee
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

6.  Upregulation of signalase processing and induction of prM-E secretion by the flavivirus NS2B-NS3 protease: roles of protease components.

Authors:  V F Yamshchikov; D W Trent; R W Compans
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

7.  Encapsidation of the flavivirus kunjin replicon RNA by using a complementation system providing Kunjin virus structural proteins in trans.

Authors:  A A Khromykh; A N Varnavski; E G Westaway
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

8.  Human isolates of dengue type 1 virus induce apoptosis in mouse neuroblastoma cells.

Authors:  P Desprès; M Flamand; P E Ceccaldi; V Deubel
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

9.  An internal signal sequence directs intramembrane proteolysis of a cellular immunoglobulin domain protein.

Authors:  Thalia Robakis; Beata Bak; Shu-huei Lin; Daniel J Bernard; Peter Scheiffele
Journal:  J Biol Chem       Date:  2008-11-03       Impact factor: 5.157

10.  Extension of flavivirus protein C differentially affects early RNA synthesis and growth in mammalian and arthropod host cells.

Authors:  Sabrina Schrauf; Christian W Mandl; Lesley Bell-Sakyi; Tim Skern
Journal:  J Virol       Date:  2009-08-19       Impact factor: 5.103
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