Literature DB >> 7493652

A new embryonic stem cell line from DBA/1lacJ mice allows genetic modification in a murine model of human inflammation.

M L Roach1, J L Stock, R Byrum, B H Koller, J D McNeish.   

Abstract

The development of embryonic stem (ES) cells and their capacity to generate mice with mutations at specific loci has provided a powerful resource for functional analysis of genes in pathological processes. However, the ability to combine this technology with the large number of existing murine models of human genetic disease has been complicated by the inability to routinely generate ES cell lines from strains other than 129. Here, we report the production of a novel ES cell line derived from an inbred mouse, DBA/1lacJ. This new ES cell line undergoes homologous recombination and efficient colonization of the germline of male chimeric offspring with ES cell microinjection into C57B1/6 embryos. The DBA/1lacJ mouse is a murine model of human inflammation, therefore genetic modifications in the DBA ES cells will allow evaluation of the target gene's role in the inflammatory process.

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Year:  1995        PMID： 7493652     DOI： 10.1006/excr.1995.1403

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  16 in total

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Journal:  J Clin Invest       Date:  2003-07-03       Impact factor: 14.808

9.  Mouse embryonic stem cells lacking p38alpha and p38delta can differentiate to endothelial cells, smooth muscle cells, and epithelial cells.

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Journal:  Differentiation       Date:  2009-06-17       Impact factor: 3.880

10.  Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8).

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Journal:  Clin Exp Immunol       Date:  2009-08-06       Impact factor: 4.330
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