| Literature DB >> 7493021 |
G Proetzel1, S A Pawlowski, M V Wiles, M Yin, G P Boivin, P N Howles, J Ding, M W Ferguson, T Doetschman.
Abstract
Mice lacking TGF-beta 3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and subsequent elimination of the mid-line epithelial seam. No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.Entities:
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Year: 1995 PMID： 7493021 PMCID： PMC3855390 DOI： 10.1038/ng1295-409
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330