Literature DB >> 7493020

The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance.

J R O'Connell1, D E Weeks.   

Abstract

As genetic marker maps have improved, multipoint linkage analysis has become a crucial part of all disease mapping studies. Paradoxically, multipoint lod scores become increasingly difficult to compute, particularly as the numbers of markers, marker alleles and untyped people increase. We have solved this problem by using a novel set-recording scheme to recode each person's genotype and 'fuzzy inheritance' to infer transmission probabilities. Our approach is implemented in a memory-efficient computer program, VITESSE, for extremely rapid computation of exact multipoint likelihoods. VITESSE enables fast and precise multipoint mapping of disease loci with highly polymorphic markers.

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Year:  1995        PMID： 7493020     DOI： 10.1038/ng1295-402

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  147 in total

1.  An optimal algorithm for automatic genotype elimination.

Authors:  J R O'Connell; D E Weeks
Journal:  Am J Hum Genet       Date:  1999-12       Impact factor: 11.025

2.  Efficient multipoint linkage analysis through reduction of inheritance space.

Authors:  K Markianos; M J Daly; L Kruglyak
Journal:  Am J Hum Genet       Date:  2001-03-14       Impact factor: 11.025

3.  A novel X-linked dominant condition: X-linked congenital isolated ptosis.

Authors:  T F McMullan; A R Collins; A G Tyers; D O Robinson
Journal:  Am J Hum Genet       Date:  2000-03-14       Impact factor: 11.025

4.  Genomewide search and genetic localization of a second gene associated with autosomal dominant branchio-oto-renal syndrome: clinical and genetic implications.

Authors:  S Kumar; K Deffenbacher; H A Marres; C W Cremers; W J Kimberling
Journal:  Am J Hum Genet       Date:  2000-04-03       Impact factor: 11.025

5.  Power comparison of parametric and nonparametric linkage tests in small pedigrees.

Authors:  P C Sham; M W Lin; J H Zhao; D Curtis
Journal:  Am J Hum Genet       Date:  2000-04-11       Impact factor: 11.025

6.  Multipoint linkage analysis of the pseudoautosomal regions, using affected sibling pairs.

Authors:  J Dupuis; P Van Eerdewegh
Journal:  Am J Hum Genet       Date:  2000-06-26       Impact factor: 11.025

7.  Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.

Authors:  H M Gurling; G Kalsi; J Brynjolfson; T Sigmundsson; R Sherrington; B S Mankoo; T Read; P Murphy; E Blaveri; A McQuillin; H Petursson; D Curtis
Journal:  Am J Hum Genet       Date:  2001-03       Impact factor: 11.025

8.  The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease.

Authors:  M Parkes; M M Barmada; J Satsangi; D E Weeks; D P Jewell; R H Duerr
Journal:  Am J Hum Genet       Date:  2000-11-10       Impact factor: 11.025

Review 9.  Gene mapping by linkage and association analysis.

Authors:  R E March
Journal:  Mol Biotechnol       Date:  1999-12-01       Impact factor: 2.695

10.  Statistical approaches to gene mapping.

Authors:  J Ott; J Hoh
Journal:  Am J Hum Genet       Date:  2000-07-06       Impact factor: 11.025
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