Literature DB >> 7493019

Peroxisome assembly factor-2, a putative ATPase cloned by functional complementation on a peroxisome-deficient mammalian cell mutant.

T Tsukamoto1, S Miura, T Nakai, S Yokota, N Shimozawa, Y Suzuki, T Orii, Y Fujiki, F Sakai, A Bogaki, H Yasumo, T Osumi.   

Abstract

Rat peroxisome assembly factor-2 (PAF-2) cDNA was isolated by functional complementation of peroxisome deficiency of a mutant CHO cell line, ZP92, using transient transfection assay. This cDNA encodes a 978-amino acid protein with two putative ATP-binding sites. PAF-2 is a member of a putative ATPase family, including two yeast gene products essential for peroxisome assembly. A stable transformant of ZP92 with the cDNA was morphologically and biochemically restored for peroxisome biogenesis. Fibroblasts derived from patients deficient in peroxisome biogenesis (complementation group C) were also complemented with PAF-2 cDNA, indicating that PAF-2 is a strong candidate for the pathogenic gene of group C peroxisome deficiency.

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Year:  1995        PMID： 7493019     DOI： 10.1038/ng1295-395

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  19 in total

Review 1.  Disorders related to peroxisomal membranes.

Authors:  J Gärtner
Journal:  J Inherit Metab Dis       Date:  2000-05       Impact factor: 4.982

2.  Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol.

Authors:  Ana G Pedrosa; Tânia Francisco; Diana Bicho; Ana F Dias; Aurora Barros-Barbosa; Vera Hagmann; Gabriele Dodt; Tony A Rodrigues; Jorge E Azevedo
Journal:  J Biol Chem       Date:  2018-06-08       Impact factor: 5.157

Review 3.  The surprising complexity of peroxisome biogenesis.

Authors:  L J Olsen
Journal:  Plant Mol Biol       Date:  1998-09       Impact factor: 4.076

4.  Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes.

Authors:  K N Faber; J A Heyman; S Subramani
Journal:  Mol Cell Biol       Date:  1998-02       Impact factor: 4.272

Review 5.  Clinical, biochemical and genetic aspects and neuronal migration in peroxisome biogenesis disorders.

Authors:  Y Suzuki; N Shimozawa; A Imamura; S Fukuda; Z Zhang; T Orii; N Kondo
Journal:  J Inherit Metab Dis       Date:  2001-04       Impact factor: 4.982

6.  Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.

Authors:  Y Matsuzono; N Kinoshita; S Tamura; N Shimozawa; M Hamasaki; K Ghaedi; R J Wanders; Y Suzuki; N Kondo; Y Fujiki
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

7.  Peroxisomal metabolic function is required for appressorium-mediated plant infection by Colletotrichum lagenarium.

Authors:  A Kimura; Y Takano; I Furusawa; T Okuno
Journal:  Plant Cell       Date:  2001-08       Impact factor: 11.277

8.  Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.

Authors:  H Otera; K Okumoto; K Tateishi; Y Ikoma; E Matsuda; M Nishimura; T Tsukamoto; T Osumi; K Ohashi; O Higuchi; Y Fujiki
Journal:  Mol Cell Biol       Date:  1998-01       Impact factor: 4.272

9.  The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.

Authors:  K Ghaedi; S Tamura; K Okumoto; Y Matsuzono; Y Fujiki
Journal:  Mol Biol Cell       Date:  2000-06       Impact factor: 4.138

10.  Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D.

Authors:  M Honsho; S Tamura; N Shimozawa; Y Suzuki; N Kondo; Y Fujiki
Journal:  Am J Hum Genet       Date:  1998-12       Impact factor: 11.025
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