Literature DB >> 7493005

Does bacitracin have an absorption-enhancing effect in the intestine?

S Gotoh1, R Nakamura, M Nishiyama, T Fujita, A Yamamoto, S Muranishi.   

Abstract

We studied the absorption enhancement effects of three types of protease inhibitors, aprotinin, bacitracin and soybean trypsin inhibitor, in the rat intestine. Of these protease inhibitors, bacitracin enhanced the absorption of FD-4 and phenol red from the rat small and large intestine without mucosal toxicity. Thus, it was suggested that bacitracin has not only a protease-inhibitory but also an absorption-enhancing capability.

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Year:  1995        PMID: 7493005     DOI: 10.1248/bpb.18.794

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN: 0918-6158            Impact factor:   2.233


  3 in total

1.  Evaluation of inhibitory activity of casein on proteases in rat intestine.

Authors:  Seiji Ohtani; Kyoko Shirasu; Ken-ichi Ogawara; Kazutaka Higaki; Toshikiro Kimura
Journal:  Pharm Res       Date:  2003-04       Impact factor: 4.200

2.  Inhibition of binding of an enzymatically stable thrombin inhibitor to lumenal proteases as an additional mechanism of intestinal absorption enhancement.

Authors:  M Sjöström; L Lindfors; A L Ungell
Journal:  Pharm Res       Date:  1999-01       Impact factor: 4.200

3.  Permeability characteristics of tetragastrins across intestinal membranes using the Caco-2 monolayer system: comparison between acylation and application of protease inhibitors.

Authors:  T Fujita; I Kawahara; Y Quan; K Hattori; K Takenaka; S Muranishi; A Yamamoto
Journal:  Pharm Res       Date:  1998-09       Impact factor: 4.200

  3 in total

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