Literature DB >> 7492331

Degradation of purines: only ureidoglycollate lyase out of four allantoin-degrading enzymes is present in mammals.

S Fujiwara1, T Noguchi.   

Abstract

It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution. However, surprisingly, ureidoglycollate lyase has been found in a mammalian tissue. Ureidoglycollate lyase was purified to homogeneity and characterized from rat-liver mitochondria. The apparent Km (17 mM) of the rat enzyme for ureidoglycollate was much higher than that (0.33 mM) of fish-liver ureidoglycollate lyase. The rat-liver enzyme differed from the fish-liver enzyme in enzymic, physical and immunological properties.

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Year:  1995        PMID: 7492331      PMCID: PMC1136261          DOI: 10.1042/bj3120315

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  14 in total

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Authors:  T Noguchi; E Okuno; Y Takada; Y Minatogawa; K Okai; R Kido
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9.  Ureidoglycollate lyase, a new metalloenzyme of peroxisomal urate degradation in marine fish liver.

Authors:  Y Takada; T Noguchi
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

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Authors:  Y Takada; T Noguchi
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