| Literature DB >> 7492331 |
Abstract
It is generally accepted that all of the allantoin-degrading enzymes (allantoinase, allantoicase, ureidoglycollate lyase and urease), used in purine degradation, were lost during mammalian evolution. However, surprisingly, ureidoglycollate lyase has been found in a mammalian tissue. Ureidoglycollate lyase was purified to homogeneity and characterized from rat-liver mitochondria. The apparent Km (17 mM) of the rat enzyme for ureidoglycollate was much higher than that (0.33 mM) of fish-liver ureidoglycollate lyase. The rat-liver enzyme differed from the fish-liver enzyme in enzymic, physical and immunological properties.Entities:
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Year: 1995 PMID: 7492331 PMCID: PMC1136261 DOI: 10.1042/bj3120315
Source DB: PubMed Journal: Biochem J ISSN: 0264-6021 Impact factor: 3.857