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Literature DB >> 7492109

In vitro activity of the semisynthetic glycopeptide amide MDL 63,246.

Abstract

The in vitro activity of the semisynthetic glycopeptide amide MDL 63,246 against 293 U.S. clinical isolates of gram-positive cocci was determined by the broth microdilution method. When compared with teicoplanin, MDL 63,246 had improved activity against Staphylococcus epidermidis (MICs that inhibited 90% strains tested [MIC90s], 0.25 versus 8 micrograms/ml, respectively). Staphylococcus haemolyticus (MIC90s, 1 versus 32 micrograms/ml, respectively), and VanA Enterococcus faecium (MIC90s, 32 versus > or = 1,024 micrograms/ml, respectively).

Entities: Chemical Species

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Year: 1995 PMID： 7492109 PMCID： PMC162786 DOI： 10.1128/AAC.39.7.1589

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

11 in total

1. Evaluation of the teicoplanin broth microdilution and disk diffusion susceptibility tests and recommended interpretive criteria.

Authors: M T Kenny; G D Mayer; J K Dulworth; M A Brackman; K Farrar
Journal: Diagn Microbiol Infect Dis Date: 1992 Sep-Oct Impact factor: 2.803

2. Antimicrobial activity of MDL 62,873, a semisynthetic derivative of teicoplanin, in vitro and in experimental infections.

Authors: M Berti; G Candiani; M Borgonovi; P Landini; F Ripamonti; R Scotti; L Cavenaghi; M Denaro; B P Goldstein
Journal: Antimicrob Agents Chemother Date: 1992-02 Impact factor: 5.191

3. A40926, a new glycopeptide antibiotic with anti-Neisseria activity.

Authors: B P Goldstein; E Selva; L Gastaldo; M Berti; R Pallanza; F Ripamonti; P Ferrari; M Denaro; V Arioli; G Cassani
Journal: Antimicrob Agents Chemother Date: 1987-12 Impact factor: 5.191

Review 4. Genetics and mechanisms of glycopeptide resistance in enterococci.

Authors: M Arthur; P Courvalin
Journal: Antimicrob Agents Chemother Date: 1993-08 Impact factor: 5.191

Review 5. Glycopeptide resistance in gram-positive bacteria: from black and white to shades of grey.

Authors: N Woodford; A P Johnson
Journal: J Med Microbiol Date: 1994-06 Impact factor: 2.472

6. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.

Authors: M Arthur; C Molinas; P Courvalin
Journal: J Bacteriol Date: 1992-04 Impact factor: 3.490

7. Synthesis and biological properties of N63-carboxamides of teicoplanin antibiotics. Structure-activity relationships.

Authors: A Malabarba; A Trani; P Strazzolini; G Cietto; P Ferrari; G Tarzia; R Pallanza; M Berti
Journal: J Med Chem Date: 1989-11 Impact factor: 7.446

8. Comparative in vitro activity of teicoplanin and vancomycin against United States teicoplanin clinical trial isolates of gram-positive cocci.

Authors: M T Kenny; J K Dulworth; M A Brackman
Journal: Diagn Microbiol Infect Dis Date: 1991 Jan-Feb Impact factor: 2.803

9. Activities of two new teicoplanin amide derivatives (MDL 62211 and MDL 62873) compared with activities of teicoplanin and vancomycin against 800 recent staphylococcal isolates from France and the United States.

Authors: R N Jones; F W Goldstein; X Y Zhou
Journal: Antimicrob Agents Chemother Date: 1991-03 Impact factor: 5.191

In vitro activity of the semisynthetic glycopeptide amide MDL 63,246.

1. Evaluation of the teicoplanin broth microdilution and disk diffusion susceptibility tests and recommended interpretive criteria.

2. Antimicrobial activity of MDL 62,873, a semisynthetic derivative of teicoplanin, in vitro and in experimental infections.

3. A40926, a new glycopeptide antibiotic with anti-Neisseria activity.

Review 4. Genetics and mechanisms of glycopeptide resistance in enterococci.

Review 5. Glycopeptide resistance in gram-positive bacteria: from black and white to shades of grey.

6. The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.

7. Synthesis and biological properties of N63-carboxamides of teicoplanin antibiotics. Structure-activity relationships.

8. Comparative in vitro activity of teicoplanin and vancomycin against United States teicoplanin clinical trial isolates of gram-positive cocci.

9. Activities of two new teicoplanin amide derivatives (MDL 62211 and MDL 62873) compared with activities of teicoplanin and vancomycin against 800 recent staphylococcal isolates from France and the United States.

10. Antimicrobial activity of MDL 63,246, a new semisynthetic glycopeptide antibiotic.

1. Semisynthetic glycopeptide antibiotics derived from LY264826 active against vancomycin-resistant enterococci.

2. Pharmacokinetics of MDL 63,246, a new semisynthetic glycopeptide antibiotic, in the rat.

Review 3. Glycopeptide antibiotics: from conventional molecules to new derivatives.

4. Antimicrobial activity of MDL 63,246, a new semisynthetic glycopeptide antibiotic.