Literature DB >> 7491710

Analysis of competitive agonist-antagonist interactions by nonlinear regression.

M J Lew1, J A Angus.   

Abstract

The rigorous estimation of a dissociation constant (Kb) for antagonists in functional assays has been sought by pharmacologists using a variety of techniques ever since the regression method of Arunlakshana and Schild in 1959. Here, Michael Lew and James Angus describe a simplified global regression method with improved accuracy compared to Schild analysis. The method is suitable for personal computers with standard graphing and statistical software. The accuracy of the predicted pKb values and confidence intervals has been tested by comparing examples of published data, and by mathematical (bootstrap) simulations.

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Year:  1995        PMID： 7491710     DOI： 10.1016/s0165-6147(00)89066-5

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  39 in total

1.  Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens.

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2.  Characterization of excitatory prostanoid receptors in the human umbilical artery in vitro.

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3.  Microscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.

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Review 4.  Matching models to data: a receptor pharmacologist's guide.

Authors:  David A Hall; Christopher J Langmead
Journal:  Br J Pharmacol       Date:  2010-11       Impact factor: 8.739

5.  Characterization and tissue location of the neural adenosine receptor in the rat ileum.

Authors:  I M Coupar
Journal:  Br J Pharmacol       Date:  1999-03       Impact factor: 8.739

6.  Potentiation of NF-kappaB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.

Authors:  N S Holden; W Gong; E M King; M Kaur; M A Giembycz; R Newton
Journal:  Br J Pharmacol       Date:  2007-09-24       Impact factor: 8.739

7.  Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists.

Authors:  R Nonno; M Pannacci; V Lucini; D Angeloni; F Fraschini; B M Stankov
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

8.  Piglet saphenous vein contains multiple relaxatory prostanoid receptors: evidence for EP4, EP2, DP and IP receptor subtypes.

Authors:  Richard J Wilson; Heather Giles
Journal:  Br J Pharmacol       Date:  2005-02       Impact factor: 8.739

9.  Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro.

Authors:  K L Aughton; K Hamilton-Smith; J Gupta; J S Morton; C P Wayman; V M Jackson
Journal:  Br J Pharmacol       Date:  2008-06-30       Impact factor: 8.739

10.  Autoantibodies enhance agonist action and binding to cardiac muscarinic receptors in chronic Chagas' disease.

Authors:  Ciria C Hernandez; Jose H Nascimento; Elen A Chaves; Patricia C Costa; Masako O Masuda; Eleonora Kurtenbach; Antonio C Campos DE Carvalho; Luis E Gimenez
Journal:  J Recept Signal Transduct Res       Date:  2008       Impact factor: 2.092
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