Literature DB >> 7491287

A Gi1-2-protein is required for alpha 2A-adrenoceptor-induced stimulation of voltage-dependent Ca2+ channels in rat portal vein myocytes.

N Macrez-Leprêtre1, J Ibarrondo, S Arnaudeau, J L Morel, G Guillon, J Mironneau.   

Abstract

In rat portal vein myocytes, alpha 2A-adrenoceptors activate voltage-dependent Ca2+ channels via a transduction pathway requiring protein kinase C activation mediated by a pertussis-toxin-sensitive G-protein. As revealed by the use of antibodies directed against the different alpha-subunits expressed in portal vein myocytes, we show that the clonidine-induced stimulation of voltage-dependent Ca2+ channels is mainly mediated by a Gi1-2-protein.

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Year:  1995        PMID： 7491287     DOI： 10.1007/bf00373897

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  8 in total

Review 1.  Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction.

Authors:  A M Spiegel; A Shenker; L S Weinstein
Journal:  Endocr Rev       Date:  1992-08       Impact factor: 19.871

2.  Specific antibodies against Go isoforms reveal the early expression of the Go2 alpha subunit and appearance of Go1 alpha during neuronal differentiation.

Authors:  B Rouot; N Charpentier; C Chabbert; J Carrette; R Zumbihl; J Bockaert; V Homburger
Journal:  Mol Pharmacol       Date:  1992-02       Impact factor: 4.436

3.  Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles.

Authors:  H Kurose; J W Regan; M G Caron; R J Lefkowitz
Journal:  Biochemistry       Date:  1991-04-02       Impact factor: 3.162

4.  Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.

Authors:  A Remaury; D Larrouy; D Daviaud; B Rouot; H Paris
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857

5.  Both alpha 1A- and alpha 2A-adrenoreceptor subtypes stimulate voltage-operated L-type calcium channels in rat portal vein myocytes. Evidence for two distinct transduction pathways.

Authors:  N Leprêtre; J Mironneau; J L Morel
Journal:  J Biol Chem       Date:  1994-11-25       Impact factor: 5.157

6.  Gi2 and protein kinase C are required for thyrotropin-releasing hormone-induced stimulation of voltage-dependent Ca2+ channels in rat pituitary GH3 cells.

Authors:  M Gollasch; C Kleuss; J Hescheler; B Wittig; G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

7.  Alpha 2-adrenoceptors activate dihydropyridine-sensitive calcium channels via Gi-proteins and protein kinase C in rat portal vein myocytes.

Authors:  N Leprêtre; J Mironneau
Journal:  Pflugers Arch       Date:  1994-12       Impact factor: 3.657

8.  Evidence for two molecular forms of solubilized vasopressin receptors in rat kidney membranes. Regulation by guanyl nucleotides.

Authors:  G Guillon; D Butlen; R Rajerison
Journal:  Mol Pharmacol       Date:  1984-09       Impact factor: 4.436
  8 in total
  1 in total

1.  Beta-3 adrenergic stimulation of L-type Ca(2+) channels in rat portal vein myocytes.

Authors:  P Viard; N Macrez; F Coussin; J L Morel; J Mironneau
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739
  1 in total

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