Literature DB >> 7489918

Genomic organization of the mycobacterial sigma gene cluster.

L Doukhan1, M Predich, G Nair, O Dussurget, I Mandic-Mulec, S T Cole, D R Smith, I Smith.   

Abstract

We have previously described sigma A and sigma B and their structural genes, mysA and mysB, respectively, in Mycobacterium smegmatis. We have now sequenced the corresponding regions in the M. tuberculosis and M. leprae chromosomes, and have found the two homologous genes. The chromosomal linkage and the deduced amino acid (aa) sequences of the two genes show very high similarity in the three species of mycobacteria. We also report the finding of two other open reading frames (ORF) in these clusters. orfX, which has an unknown function, is located between mysA and mysB. The other ORF, located downstream from mysB, encodes a homolog of DtxR, the iron regulatory protein from Corynebacterium diphtheriae (Cd).

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Year:  1995        PMID： 7489918     DOI： 10.1016/0378-1119(95)00427-8

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  30 in total

1.  Anion-coordinating residues at binding site 1 are essential for the biological activity of the diphtheria toxin repressor.

Authors:  J Goranson-Siekierke; E Pohl; W G Hol; R K Holmes
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

Review 2.  Sigma factors and global gene regulation in Mycobacterium tuberculosis.

Authors:  Riccardo Manganelli; Roberta Provvedi; Sebastien Rodrigue; Jocelyn Beaucher; Luc Gaudreau; Issar Smith; Roberta Proveddi
Journal:  J Bacteriol       Date:  2004-02       Impact factor: 3.490

3.  Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis.

Authors:  Yukari C Manabe; Christine L Hatem; Anup K Kesavan; Justin Durack; John R Murphy
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

Review 4.  Alternative sigma factors and their roles in bacterial virulence.

Authors:  Mark J Kazmierczak; Martin Wiedmann; Kathryn J Boor
Journal:  Microbiol Mol Biol Rev       Date:  2005-12       Impact factor: 11.056

5.  Identification and characterization of three new promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron.

Authors:  J H Lee; T Wang; K Ault; J Liu; M P Schmitt; R K Holmes
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

6.  Construction and characterization of a Mycobacterium tuberculosis mutant lacking the alternate sigma factor gene, sigF.

Authors:  P Chen; R E Ruiz; Q Li; R F Silver; W R Bishai
Journal:  Infect Immun       Date:  2000-10       Impact factor: 3.441

7.  Transcription of two sigma 70 homologue genes, sigA and sigB, in stationary-phase Mycobacterium tuberculosis.

Authors:  Y Hu; A R Coates
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

8.  Strategies used by pathogenic and nonpathogenic mycobacteria to synthesize rRNA.

Authors:  J A Gonzalez-y-Merchand; M J Garcia; S Gonzalez-Rico; M J Colston; R A Cox
Journal:  J Bacteriol       Date:  1997-11       Impact factor: 3.490

9.  Molecular systematic studies of eubacteria, using sigma70-type sigma factors of group 1 and group 2.

Authors:  T M Gruber; D A Bryant
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

10.  Transcription of the contiguous sigB, dtxR, and galE genes in Corynebacterium diphtheriae: evidence for multiple transcripts and regulation by environmental factors.

Authors:  Diana Marra Oram; Andrew D Jacobson; Randall K Holmes
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490
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