Literature DB >> 7488040

Didemnin B induces cell death by apoptosis: the fastest induction of apoptosis ever described.

D R Grubb1, E J Wolvetang, A Lawen.   

Abstract

Didemnin B, a cyclic N-methylated peptolide induces apoptosis in human HL-60 cells. When incubated with 1 microM didemnin B, unsynchronized HL-60 cultures undergo apoptosis to 100% within 140 minutes. Apoptosis has been assessed by the typical apoptotic morphology, the presence of double-stranded DNA fragments within the cytosol and the generation of DNA ladders. None of these characteristics of apoptosis are seen when HL-60 cells are pretreated with 1mM Zn2+ immediately before treatment with didemnin B.

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Year:  1995        PMID： 7488040     DOI： 10.1006/bbrc.1995.2580

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Bioactive substances with anti-neoplastic efficacy from marine invertebrates: Bryozoa, Mollusca, Echinodermata and Urochordata.

Authors:  Peter Sima; Vaclav Vetvicka
Journal:  World J Clin Oncol       Date:  2011-11-10

2.  Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.

Authors:  Ségolène Caboche; Valérie Leclère; Maude Pupin; Gregory Kucherov; Philippe Jacques
Journal:  J Bacteriol       Date:  2010-08-06       Impact factor: 3.490

Review 3.  Drug development from marine natural products.

Authors:  Tadeusz F Molinski; Doralyn S Dalisay; Sarah L Lievens; Jonel P Saludes
Journal:  Nat Rev Drug Discov       Date:  2008-12-19       Impact factor: 84.694

Review 4.  Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology.

Authors:  Vedanjali Gogineni; Mark T Hamann
Journal:  Biochim Biophys Acta Gen Subj       Date:  2017-08-24       Impact factor: 3.770

Review 5.  Antitumor peptides from marine organisms.

Authors:  Lan-Hong Zheng; Yue-Jun Wang; Jun Sheng; Fang Wang; Yuan Zheng; Xiu-Kun Lin; Mi Sun
Journal:  Mar Drugs       Date:  2011-10-10       Impact factor: 6.085

6.  Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.

Authors:  Malia B Potts; Elizabeth A McMillan; Tracy I Rosales; Hyun Seok Kim; Yi-Hung Ou; Jason E Toombs; Rolf A Brekken; Mark D Minden; John B MacMillan; Michael A White
Journal:  Nat Chem Biol       Date:  2015-04-13       Impact factor: 15.040

7.  Isolation and characterization of marine Brevibacillus sp. S-1 collected from South China Sea and a novel antitumor peptide produced by the strain.

Authors:  Lanhong Zheng; Yao Yi; Jia Liu; Xiukun Lin; Kangli Yang; Mei Lv; Xinwen Zhou; Jianhua Hao; Junzhong Liu; Yuan Zheng; Mi Sun
Journal:  PLoS One       Date:  2014-11-05       Impact factor: 3.240

8.  Novel Marine Compounds: Anticancer or Genotoxic?

Authors:  Jamal M. Arif; Amal A. Al-Hazzani; Muhammed Kunhi; Fahad Al-Khodairy
Journal:  J Biomed Biotechnol       Date:  2004

9.  Effect of Aplidin in acute lymphoblastic leukaemia cells.

Authors:  E Erba; M Serafini; G Gaipa; G Tognon; S Marchini; N Celli; D Rotilio; M Broggini; J Jimeno; G T Faircloth; A Biondi; M D'Incalci
Journal:  Br J Cancer       Date:  2003-08-18       Impact factor: 7.640
  9 in total

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