Literature DB >> 7488038

Peroxynitrite causes apoptosis in rat thymocytes.

M G Salgo1, G L Squadrito, W A Pryor.   

Abstract

Peroxynitrite is demonstrated to cause apoptosis in freshly harvested rat thymocytes suspended in phosphate buffer, as shown by the typical ladder pattern of DNA fragmentation. This evidence suggests a new function for peroxynitrite, already known to be a strong oxidant. Peroxynitrite can nick DNA, oxidize cellular thiols and initiate the apoptotic process responsible for genomic degradation.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7488038     DOI： 10.1006/bbrc.1995.2578

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  28 in total

Review 1.  Critical illness hyperglycemia in pediatric cardiac surgery.

Authors:  Kalia P Ulate; Shekhar Raj; Alexandre T Rotta
Journal:  J Diabetes Sci Technol       Date:  2012-01-01

Review 2.  Pathophysiological roles of peroxynitrite in circulatory shock.

Authors:  Csaba Szabó; Katalin Módis
Journal:  Shock       Date:  2010-09       Impact factor: 3.454

3.  Consequences of age on ischemic wound healing in rats: altered antioxidant activity and delayed wound closure.

Authors:  Andrea N Moor; Evan Tummel; Jamie L Prather; Michelle Jung; Jonathan J Lopez; Sarah Connors; Lisa J Gould
Journal:  Age (Dordr)       Date:  2014-01-21

4.  Inducible nitric oxide synthase is a major intermediate in signaling pathways for the survival of plasma cells.

Authors:  Ankur S Saini; Gautam N Shenoy; Satyajit Rath; Vineeta Bal; Anna George
Journal:  Nat Immunol       Date:  2014-01-19       Impact factor: 25.606

5.  Effects of melatonin on the nitric oxide treated retina.

Authors:  A W Siu; G G Ortiz; G Benitez-King; C H To; R J Reiter
Journal:  Br J Ophthalmol       Date:  2004-08       Impact factor: 4.638

6.  In Vitro Study of Nitric Oxide Metabolites Effects on Human Hydatid of Echinococcus granulosus.

Authors:  Razika Zeghir-Bouteldja; Manel Amri; Saliha Aitaissa; Samia Bouaziz; Dalila Mezioug; Chafia Touil-Boukoffa
Journal:  J Parasitol Res       Date:  2009-12-13

7.  Inducible nitric oxide synthase is crucial for plasma cell survival.

Authors:  Modesta N Njau; Joshy Jacob
Journal:  Nat Immunol       Date:  2014-03       Impact factor: 25.606

8.  Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats.

Authors:  Meenakshisundaram Thiyagarajan; Chaman Lal Kaul; Shyam Sundar Sharma
Journal:  Br J Pharmacol       Date:  2004-06-14       Impact factor: 8.739

9.  Alteration of apoptotic protease activating factor 1 expression and possible role in ONOO(-)-induced apoptosis in human cerebral vascular smooth muscle cells.

Authors:  Lin Li; Dongmei Zhao; Jianfeng Li
Journal:  Int J Clin Exp Med       Date:  2015-10-15

10.  Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation.

Authors:  Laura Dugo; Stefania Marzocco; Emanuela Mazzon; Rosanna Di Paola; Tiziana Genovese; Achille P Caputi; Salvatore Cuzzocrea
Journal:  Br J Pharmacol       Date:  2004-02-09       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.