Literature DB >> 7486944

Timing of penicillin treatment influences the course of Streptococcus pneumoniae-induced middle ear inflammation.

K Sato1, M K Quartey, C L Liebeler, G S Giebink.   

Abstract

Penicillin treatment timing, using the chinchilla pneumococcal otitis media model, was investigated. Early treatment (when approximately 10(3) pneumococcal CFU/ml was present in middle ear fluid) significantly accelerated inflammatory-cell influx, whereas late treatment (with approximately 10(7) pneumococcal CFU/ml present in middle ear fluid) did not. Therefore, antiinflammatory interventions will be needed early in the course of inflammation.

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Year:  1995        PMID： 7486944      PMCID： PMC162851          DOI： 10.1128/AAC.39.8.1896

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

Review 1.  The microbiology of otitis media.

Authors:  G S Giebink
Journal:  Pediatr Infect Dis J       Date:  1989-01       Impact factor: 2.129

2.  The contribution of pneumococcal cell wall to the pathogenesis of experimental otitis media.

Authors:  M L Ripley-Petzoldt; G S Giebink; S K Juhn; D Aeppli; A Tomasz; E Tuomanen
Journal:  J Infect Dis       Date:  1988-02       Impact factor: 5.226

3.  Influence of antibiotic dose, dosing interval, and duration of therapy on outcome in experimental pneumococcal meningitis in rabbits.

Authors:  M G Täuber; S Kunz; O Zak; M A Sande
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

4.  Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis.

Authors:  E Tuomanen; B Hengstler; R Rich; M A Bray; O Zak; A Tomasz
Journal:  J Infect Dis       Date:  1987-05       Impact factor: 5.226

5.  Detection of pneumococcal capsular antigen in the presence of penicillin in vitro.

Authors:  Y Holloway; W G Boersma; H Kuttschrütter; J A Snijder
Journal:  Scand J Infect Dis       Date:  1993

6.  Detection of Pneumococcal Capsular polysaccharide antigens by latex agglutination, counterimmunoelectrophoresis, and radioimmunoassay in middle ear exudates in acute otitis media.

Authors:  M K Leinonen
Journal:  J Clin Microbiol       Date:  1980-02       Impact factor: 5.948

7.  The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis.

Authors:  E Tuomanen; A Tomasz; B Hengstler; O Zak
Journal:  J Infect Dis       Date:  1985-03       Impact factor: 5.226

8.  The bacteriology and cytology of chronic otitis media with effusion.

Authors:  G S Giebink; S K Juhn; M L Weber; C T Le
Journal:  Pediatr Infect Dis       Date:  1982 Mar-Apr

9.  The induction of meningeal inflammation by components of the pneumococcal cell wall.

Authors:  E Tuomanen; H Liu; B Hengstler; O Zak; A Tomasz
Journal:  J Infect Dis       Date:  1985-05       Impact factor: 5.226

10.  Experimental animal models for studying antimicrobial pharmacokinetics in otitis media.

Authors:  D M Canafax; N Nonomura; G R Erdmann; C T Le; S K Juhn; G S Giebink
Journal:  Pharm Res       Date:  1989-04       Impact factor: 4.200
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  5 in total

1.  Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model.

Authors:  K Sato; C L Liebeler; M K Quartey; C T Le; G S Giebink
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

Review 2.  Bacterial endophthalmitis: epidemiology, therapeutics, and bacterium-host interactions.

Authors:  Michelle C Callegan; Michael Engelbert; David W Parke; Bradley D Jett; Michael S Gilmore
Journal:  Clin Microbiol Rev       Date:  2002-01       Impact factor: 26.132

3.  Development of experimental pneumonia by infection with penicillin-insensitive Streptococcus pneumoniae in guinea pigs and their treatment with amoxicillin, cefotaxime, and meropenem.

Authors:  C Ponte; A Parra; E Nieto; F Soriano
Journal:  Antimicrob Agents Chemother       Date:  1996-12       Impact factor: 5.191

4.  Estimating amoxicillin influx/efflux in chinchilla middle ear fluid and simultaneous measurement of antibacterial effect.

Authors:  Yue Huang; Zheng Yang; Linda Cartier; Belinda Cheung; Ronald J Sawchuk
Journal:  Antimicrob Agents Chemother       Date:  2007-10-08       Impact factor: 5.191

5.  Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model.

Authors:  K Sato; M K Quartey; C L Liebeler; C T Le; G S Giebink
Journal:  Infect Immun       Date:  1996-04       Impact factor: 3.441
  5 in total

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