OBJECTIVE: Data suggest that serotonin activity is reduced in women at normal weight who have bulimia nervosa. The authors tested whether acute perturbations in serotonin activity could alter short-term eating behavior and mood. METHOD: They examined the effect of acute tryptophan depletion in 10 women with and 10 women without bulimia nervosa. RESULTS: Women with bulimia nervosa exhibited an increase in caloric intake and mood irritability after acute tryptophan depletion. CONCLUSIONS: These results indicate that women with bulimia nervosa have an exaggerated or pathological response to transient alterations in serotonin activity.
OBJECTIVE: Data suggest that serotonin activity is reduced in women at normal weight who have bulimia nervosa. The authors tested whether acute perturbations in serotonin activity could alter short-term eating behavior and mood. METHOD: They examined the effect of acute tryptophan depletion in 10 women with and 10 women without bulimia nervosa. RESULTS:Women with bulimia nervosa exhibited an increase in caloric intake and mood irritability after acute tryptophan depletion. CONCLUSIONS: These results indicate that women with bulimia nervosa have an exaggerated or pathological response to transient alterations in serotonin activity.
Authors: Nassima Ait-Daoud; John D Roache; Michael A Dawes; Lei Liu; Xin-Qun Wang; Martin A Javors; Chamindi Seneviratne; Bankole A Johnson Journal: Alcohol Clin Exp Res Date: 2009-05-04 Impact factor: 3.455
Authors: Rachel Koren; Alexis E Duncan; Melissa A Munn-Chernoff; Kathleen K Bucholz; Michael T Lynskey; Andrew C Heath; Arpana Agrawal Journal: Psychiatr Genet Date: 2014-02 Impact factor: 2.458
Authors: Kenneth R Bruce; Howard Steiger; Simon N Young; N M K Ng Ying Kin; Mimi Israël; Mélissa Lévesque Journal: J Psychiatry Neurosci Date: 2009-09 Impact factor: 6.186
Authors: Dawn M Richard; Michael A Dawes; Charles W Mathias; Ashley Acheson; Nathalie Hill-Kapturczak; Donald M Dougherty Journal: Int J Tryptophan Res Date: 2009-03-23
Authors: Donald M Dougherty; Dawn M Marsh; Charles W Mathias; Michael A Dawes; Don M Bradley; Chris J Morgan; Abdulla A-B Badawy Journal: Psychopharmacology (Berl) Date: 2007-03-22 Impact factor: 4.415