Literature DB >> 7485231

Why is the reproductive performance lower in Becker (BMD) as compared to limb girdle (LGMD) muscular dystrophy male patients?

S Eggers1, V Lauriano, M Melo, R I Takata, J Akiyama, M R Passos-Bueno, V Gentil, O Frota-Pessoa, M Zatz.   

Abstract

We had previously reported that patients affected with BMD have a significantly reduced reproductive performance (f = 0.12) as compared to male LGMD patients of similar age and physical impairment (f = 0.98). In the present study parameters such as the socio-economic level, as well as psychosocial, intellectual, and psychiatric functionings could not explain the low fitness of BMD patients. The effect of genetic counseling, a greater difficulty in coping with the disease, and relating to women and/or a potential malfunction of reproductive physiology are discussed as possible causes.

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Year:  1995        PMID: 7485231     DOI: 10.1002/ajmg.1320600106

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN: 0148-7299


  2 in total

1.  How the magnitude of clinical severity and recurrence risk affects reproductive decisions in adult males with different forms of progressive muscular dystrophy.

Authors:  S Eggers; M Zatz
Journal:  J Med Genet       Date:  1998-03       Impact factor: 6.318

2.  Profound human/mouse differences in alpha-dystrobrevin isoforms: a novel syntrophin-binding site and promoter missing in mouse and rat.

Authors:  Sabrina V Böhm; Panayiotis Constantinou; Sipin Tan; Hong Jin; Roland G Roberts
Journal:  BMC Biol       Date:  2009-12-04       Impact factor: 7.431

  2 in total

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