PURPOSE: To characterize temporal changes in signal intensity patterns of multiple sclerosis lesions on serial MR. METHODS: T1-, T2-, proton density-, and contrast-enhanced T1-weighted MR was performed on five patients with relapsing-remitting multiple sclerosis at least 22 times in the course of 1 year. RESULTS: Forty-three enhancing lesions and 1 new lesion that never showed enhancement were detected and followed for periods ranging from approximately 4 weeks to 1 year (total of 702 time points). At first detection the center of new lesions was brighter than the periphery (20 of 24 new lesions on proton density-weighted and 19 of 23 new lesions on contrast-enhanced images). On contrast-enhanced images, ring hyperintensity was predominant at time points later than 29 days. As lesions aged, a residual rim of "nonenhancing" hyperintensity often was noted on contrast-enhanced images. Some older lesions (> 1 year) showed similar appearance on unenhanced T1-weighted images. On proton density-weighted images ring hyperintensity was most frequent 2 to 4 months after lesion detection. The estimated average duration of gadopentetate dimeglumine enhancement was 1 to 2 months. CONCLUSIONS: A lesion evolution pattern relevant to MR was inferred. We believe that specific information about the histopathologic evolution of a lesion may be extracted not only from contrast-enhanced but also from nonenhanced serial MR. Assessment of drugs targeting specific phases of lesion evolution could benefit from quantitative pattern analysis of routine MR images.
PURPOSE: To characterize temporal changes in signal intensity patterns of multiple sclerosis lesions on serial MR. METHODS: T1-, T2-, proton density-, and contrast-enhanced T1-weighted MR was performed on five patients with relapsing-remitting multiple sclerosis at least 22 times in the course of 1 year. RESULTS: Forty-three enhancing lesions and 1 new lesion that never showed enhancement were detected and followed for periods ranging from approximately 4 weeks to 1 year (total of 702 time points). At first detection the center of new lesions was brighter than the periphery (20 of 24 new lesions on proton density-weighted and 19 of 23 new lesions on contrast-enhanced images). On contrast-enhanced images, ring hyperintensity was predominant at time points later than 29 days. As lesions aged, a residual rim of "nonenhancing" hyperintensity often was noted on contrast-enhanced images. Some older lesions (> 1 year) showed similar appearance on unenhanced T1-weighted images. On proton density-weighted images ring hyperintensity was most frequent 2 to 4 months after lesion detection. The estimated average duration of gadopentetate dimeglumine enhancement was 1 to 2 months. CONCLUSIONS: A lesion evolution pattern relevant to MR was inferred. We believe that specific information about the histopathologic evolution of a lesion may be extracted not only from contrast-enhanced but also from nonenhanced serial MR. Assessment of drugs targeting specific phases of lesion evolution could benefit from quantitative pattern analysis of routine MR images.
Authors: Guillaume Taieb; Alberto Duran-Peña; Nicolas Menjot de Chamfleur; Antoine Moulignier; Eric Thouvenot; Thibaut Allou; Arnaud Lacour; Khe Hoang-Xuan; Jean Pelletier; Pierre Labauge Journal: Neuroradiology Date: 2015-12-23 Impact factor: 2.804
Authors: Daniel S Reich; Richard White; Irene Cm Cortese; Luisa Vuolo; Colin D Shea; Tassie L Collins; John Petkau Journal: Mult Scler Date: 2015-02-06 Impact factor: 6.312
Authors: T Duval; S Le Vy; N Stikov; J Campbell; A Mezer; T Witzel; B Keil; V Smith; L L Wald; E Klawiter; J Cohen-Adad Journal: Neuroimage Date: 2016-09-22 Impact factor: 6.556
Authors: Y Zhang; S A Gauthier; A Gupta; L Tu; J Comunale; G C-Y Chiang; W Chen; C A Salustri; W Zhu; Y Wang Journal: AJNR Am J Neuroradiol Date: 2016-06-30 Impact factor: 3.825