Literature DB >> 7483294

Changes in the NS gene of neurovirulent strains of influenza affect splicing.

A C Ward1, A A Azad, J L McKimm-Breschkin.   

Abstract

The nonstructural (NS) gene has been identified as an accessory factor in determining neurovirulence for influenza A virus. The nucleotide sequence of the NS gene of the neurovirulent variant A/NWS/33 was determined and compared with its parent, A/WS/33. Alterations in the mRNA structure of the gene were observed that serve to mask the 3' splice site. Changes in this region were shown to correlate with reduced splicing of the NS gene in neurovirulent strains.

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Year:  1995        PMID： 7483294     DOI： 10.1007/bf01724301

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  19 in total

1.  Analysis of influenza A virus temperature-sensitive mutants with mutations in RNA segment 8.

Authors:  E Hatada; M Hasegawa; K Shimizu; M Hatanaka; R Fukuda
Journal:  J Gen Virol       Date:  1990-06       Impact factor: 3.891

2.  Mutation in NS2, a nonstructural protein of influenza A virus, extragenically causes aberrant replication and expression of the PA gene and leads to generation of defective interfering particles.

Authors:  T Odagiri; K Tobita
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

3.  Replication of H1N1 influenza viruses in cultured mouse embryo brain cells: virus strain and cell differentiation affect synthesis of proteins encoded in RNA segments 7 and 8 and efficiency of mRNA splicing.

Authors:  G L Bradshaw; C D Schwartz; R W Schlesinger
Journal:  Virology       Date:  1990-06       Impact factor: 3.616

4.  Complete nucleotide sequence of the non-structural gene of the human influenza virus strain A/WS/33.

Authors:  A C Ward; A A Azad; I G Macreadie; J L McKimm-Breschkin
Journal:  Nucleic Acids Res       Date:  1993-05-11       Impact factor: 16.971

5.  Molecular assembly of influenza virus: association of the NS2 protein with virion matrix.

Authors:  J Yasuda; S Nakada; A Kato; T Toyoda; A Ishihama
Journal:  Virology       Date:  1993-09       Impact factor: 3.616

6.  Neurovirulence of influenza virus in mice. II. Mechanism of virulence as studied in a neuroblastoma cell line.

Authors:  S Nakajima; A Sugiura
Journal:  Virology       Date:  1980-03       Impact factor: 3.616

7.  A 36 nucleotide deletion mutation in the coding region of the NS1 gene of an influenza A virus RNA segment 8 specifies a temperature-dependent host range phenotype.

Authors:  M H Snyder; W T London; H F Maassab; R M Chanock; B R Murphy
Journal:  Virus Res       Date:  1990-01       Impact factor: 3.303

8.  Influenza virus NS1 protein stimulates translation of the M1 protein.

Authors:  K Enami; T A Sato; S Nakada; M Enami
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

9.  Specific changes in the M1 protein during adaptation of influenza virus to mouse.

Authors:  A C Ward
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

10.  A STUDY OF THE NEUROTROPIC TENDENCY IN STRAINS OF THE VIRUS OF EPIDEMIC INFLUENZA.

Authors:  T Francis; A E Moore
Journal:  J Exp Med       Date:  1940-11-30       Impact factor: 14.307
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  3 in total

1.  Changes in the neuraminidase of neurovirulent influenza virus strains.

Authors:  A C Ward
Journal:  Virus Genes       Date:  1995       Impact factor: 2.332

2.  Expression and analysis of the NS2 protein of influenza A virus.

Authors:  A C Ward; L A Castelli; A C Lucantoni; J F White; A A Azad; I G Macreadie
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

3.  A compensatory mutagenesis study of a conserved hairpin in the M gene segment of influenza A virus shows its role in virus replication.

Authors:  M I Spronken; C E van de Sandt; E P de Jongh; O Vuong; S van der Vliet; T M Bestebroer; R C L Olsthoorn; G F Rimmelzwaan; R A M Fouchier; A P Gultyaev
Journal:  RNA Biol       Date:  2017-07-21       Impact factor: 4.652
  3 in total

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