Literature DB >> 7483165

Gene therapy to restore prostacyclin presence to injured endothelium.

J T Willerson1, P Zoldhelyi, R Meidell, J McNatt, X M Xu, K K Wu.   

Abstract

These preliminary studies demonstrate the feasibility of restoration of prostacyclin synthesis in mechanically-injured porcine carotid arteries following angioplasty. Our initial data suggest the possibility of inhibiting thrombus development by adenovirus-CMV-PGHS-1 therapy in the initial 10 days following angioplasty.

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Year:  1995        PMID： 7483165      PMCID： PMC2376524     

Source DB:  PubMed          Journal:  Trans Am Clin Climatol Assoc        ISSN： 0065-7778


  37 in total

Review 1.  Endothelial cells in hemostasis, thrombosis, and inflammation.

Authors:  K K Wu
Journal:  Hosp Pract (Off Ed)       Date:  1992-04-15

2.  Platelet aggregation in partially obstructed vessels and its elimination with aspirin.

Authors:  J D Folts; E B Crowell; G G Rowe
Journal:  Circulation       Date:  1976-09       Impact factor: 29.690

3.  Clopidogrel is more effective than aspirin in preventing coronary artery reocclusion after thrombolysis.

Authors:  S K Yao; J C Ober; J J Ferguson; J P Maffrand; H V Anderson; L M Buja; J T Willerson
Journal:  Trans Assoc Am Physicians       Date:  1993

4.  Active oxygen species play a role in mediating platelet aggregation and cyclic flow variations in severely stenosed and endothelium-injured coronary arteries.

Authors:  S K Yao; J C Ober; A Gonenne; F J Clubb; A Krishnaswami; J J Ferguson; H V Anderson; M Gorecki; L M Buja; J T Willerson
Journal:  Circ Res       Date:  1993-11       Impact factor: 17.367

5.  Short-term and long-term role of platelet activating factor as a mediator of in vivo platelet aggregation.

Authors:  P Golino; G Ambrosio; M Ragni; I Pascucci; M Triggiani; A Oriente; J McNatt; L M Buja; M Condorelli; M Chiariello
Journal:  Circulation       Date:  1993-09       Impact factor: 29.690

6.  Enhanced prostacyclin synthesis in endothelial cells by retrovirus-mediated transfer of prostaglandin H synthase cDNA.

Authors:  X M Xu; K Ohashi; S K Sanduja; K H Ruan; L H Wang; K K Wu
Journal:  J Clin Invest       Date:  1993-04       Impact factor: 14.808

7.  Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primates.

Authors:  S K Yao; J McNatt; K Cui; H V Anderson; J P Maffrand; L M Buja; J T Willerson
Journal:  Circulation       Date:  1993-12       Impact factor: 29.690

8.  Cyclic flow variations after coronary angioplasty in humans: clinical and angiographic characteristics and elimination with 7E3 monoclonal antiplatelet antibody.

Authors:  H V Anderson; R L Kirkeeide; A Krishnaswami; L A Weigelt; M Revana; H F Weisman; J T Willerson
Journal:  J Am Coll Cardiol       Date:  1994-04       Impact factor: 24.094

9.  Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction.

Authors:  M A DeWood; J Spores; R Notske; L T Mouser; R Burroughs; M S Golden; H T Lang
Journal:  N Engl J Med       Date:  1980-10-16       Impact factor: 91.245

10.  Randomised trial of coronary intervention with antibody against platelet IIb/IIIa integrin for reduction of clinical restenosis: results at six months. The EPIC Investigators.

Authors:  E J Topol; R M Califf; H F Weisman; S G Ellis; J E Tcheng; S Worley; R Ivanhoe; B S George; D Fintel; M Weston
Journal:  Lancet       Date:  1994-04-09       Impact factor: 79.321
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