Literature DB >> 7482764

What to do at an end: DNA double-strand-break repair.

D T Weaver1.   

Abstract

Repairing chromosome breaks is essential to cell survival. A major lethal effect of ionizing radiation (IR) damage is the creation of double-strand DNA breaks. Recently, a number of mammalian cell mutants that are sensitive to IR damage have been described, revealing a unique repair pathway. The DNA-dependent protein kinase (DNA-PK) is necessary for double-strand-break repair and lymphoid V(D)J recombination. DNA-PK consists of three subunits: the Ku autoantigen heterodimer and a kinase (DNA-PKCS) that is deficient in mouse scid mutant cells.

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Year:  1995        PMID： 7482764     DOI： 10.1016/s0168-9525(00)89121-0

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  43 in total

1.  Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells.

Authors:  E Sonoda; M S Sasaki; C Morrison; Y Yamaguchi-Iwai; M Takata; S Takeda
Journal:  Mol Cell Biol       Date:  1999-07       Impact factor: 4.272

2.  Visualization of repair of double-strand breaks in the bacteriophage T7 genome without normal DNA replication.

Authors:  Y T Lai; W Masker
Journal:  J Bacteriol       Date:  2000-01       Impact factor: 3.490

3.  DNA damage-dependent nuclear dynamics of the Mre11 complex.

Authors:  O K Mirzoeva; J H Petrini
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

4.  p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core.

Authors:  S B Zotchev; M Protopopova; G Selivanova
Journal:  Nucleic Acids Res       Date:  2000-10-15       Impact factor: 16.971

5.  Somatic and germinal mobility of the RescueMu transposon in transgenic maize.

Authors:  M N Raizada; G L Nan; V Walbot
Journal:  Plant Cell       Date:  2001-07       Impact factor: 11.277

6.  Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Authors:  Y Gu; S Jin; Y Gao; D T Weaver; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

7.  Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells.

Authors:  Y Xiao; D T Weaver
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

8.  The controlling role of ATM in homologous recombinational repair of DNA damage.

Authors:  C Morrison; E Sonoda; N Takao; A Shinohara; K Yamamoto; S Takeda
Journal:  EMBO J       Date:  2000-02-01       Impact factor: 11.598

Review 9.  Molecular processes and radiosensitivity.

Authors:  M Z Zdzienicka
Journal:  Strahlenther Onkol       Date:  1997-09       Impact factor: 3.621

10.  Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells.

Authors:  B Piret; J Piette
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971
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