BACKGROUND: A deranged mucosal permeability, demonstrated in several studies, has been proposed to play a role in the pathogenesis of Crohn's disease. The possibility of a genetically determined alteration of paracellular transport has been indicated in some investigations. The identification of a group of monozygotic twin pairs concordant and discordant for Crohn's disease, prompted this investigation. METHODS: Intestinal absorption after an oral load of different-sized polyethylene glycols (mol.wt, 458-810) was studied as 6-h urinary recovery. The study groups comprised twins with Crohn's disease (n = 19) and their healthy twin siblings (n = 9), non-twin patients with Crohn's disease (n = 14), and healthy controls (n = 30). RESULTS: No differences were found in the absorption of polyethylene glycols between the study groups. CONCLUSION: The results give no support to the hypothesis of a genetically determined intestinal leakiness in Crohn's disease.
BACKGROUND: A deranged mucosal permeability, demonstrated in several studies, has been proposed to play a role in the pathogenesis of Crohn's disease. The possibility of a genetically determined alteration of paracellular transport has been indicated in some investigations. The identification of a group of monozygotic twin pairs concordant and discordant for Crohn's disease, prompted this investigation. METHODS: Intestinal absorption after an oral load of different-sized polyethylene glycols (mol.wt, 458-810) was studied as 6-h urinary recovery. The study groups comprised twins with Crohn's disease (n = 19) and their healthy twin siblings (n = 9), non-twin patients with Crohn's disease (n = 14), and healthy controls (n = 30). RESULTS: No differences were found in the absorption of polyethylene glycols between the study groups. CONCLUSION: The results give no support to the hypothesis of a genetically determined intestinal leakiness in Crohn's disease.
Authors: J D Söderholm; G Olaison; K H Peterson; L E Franzén; T Lindmark; M Wirén; C Tagesson; R Sjödahl Journal: Gut Date: 2002-03 Impact factor: 23.059
Authors: Åsa V Keita; Carl Mårten Lindqvist; Åke Öst; Carlos D L Magana; Ida Schoultz; Jonas Halfvarson Journal: J Crohns Colitis Date: 2018-11-09 Impact factor: 10.020