Literature DB >> 7479885

Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.

R D Miller1, J Hogg, J H Ozaki, D Gell, S P Jackson, R Riblet.   

Abstract

The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.

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Year:  1995        PMID： 7479885      PMCID： PMC40698          DOI： 10.1073/pnas.92.23.10792

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  45 in total

1.  Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency.

Authors:  W Schuler; I J Weiler; A Schuler; R A Phillips; N Rosenberg; T W Mak; J F Kearney; R P Perry; M J Bosma
Journal:  Cell       Date:  1986-09-26       Impact factor: 41.582

2.  GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase.

Authors:  S P Jackson; J J MacDonald; S Lees-Miller; R Tjian
Journal:  Cell       Date:  1990-10-05       Impact factor: 41.582

3.  Mechanism of interaction between Ku protein and DNA.

Authors:  T Mimori; J A Hardin
Journal:  J Biol Chem       Date:  1986-08-05       Impact factor: 5.157

4.  Genetic mapping of mouse T3d and T3e between Apoa1 and Ncam.

Authors:  R D Miller; J H Ozaki; R J Riblet; D P Gold
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

5.  The mouse mutation severe combined immune deficiency (scid) is on chromosome 16.

Authors:  G C Bosma; M T Davisson; N R Ruetsch; H O Sweet; L D Shultz; M J Bosma
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

6.  The scid mutation in mice causes a general defect in DNA repair.

Authors:  G M Fulop; R A Phillips
Journal:  Nature       Date:  1990-10-04       Impact factor: 49.962

7.  The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

Authors:  M R Lieber; J E Hesse; S Lewis; G C Bosma; N Rosenberg; K Mizuuchi; M J Bosma; M Gellert
Journal:  Cell       Date:  1988-10-07       Impact factor: 41.582

8.  Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8.

Authors:  J D Sipley; J C Menninger; K O Hartley; D C Ward; S P Jackson; C W Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-01       Impact factor: 11.205

9.  A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

Authors:  A Kudo; F Melchers
Journal:  EMBO J       Date:  1987-08       Impact factor: 11.598

10.  Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.

Authors:  P D'Eustachio; A L Bothwell; T K Takaro; D Baltimore; F H Ruddle
Journal:  J Exp Med       Date:  1981-04-01       Impact factor: 14.307
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  15 in total

1.  Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Authors:  Y Gu; S Jin; Y Gao; D T Weaver; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

2.  Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.

Authors:  A Puech; B Saint-Jore; B Funke; D J Gilbert; H Sirotkin; N G Copeland; N A Jenkins; R Kucherlapati; B Morrow; A I Skoultchi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

3.  Chromosomal localization of the mouse genes encoding the ERK1 and ERK2 isoforms of MAP kinases.

Authors:  M K Saba-el-Leil; D Malo; S Meloche
Journal:  Mamm Genome       Date:  1997-02       Impact factor: 2.957

4.  Molecular and biochemical characterization of xrs mutants defective in Ku80.

Authors:  B K Singleton; A Priestley; H Steingrimsdottir; D Gell; T Blunt; S P Jackson; A R Lehmann; P A Jeggo
Journal:  Mol Cell Biol       Date:  1997-03       Impact factor: 4.272

5.  Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2-/- IL-2Rγ-/- mice: a promising model for studying human disease.

Authors:  Danieli Andrade; Patricia B Redecha; Milena Vukelic; Xiaoping Qing; Giorgio Perino; Jane E Salmon; Gloria C Koo
Journal:  Arthritis Rheum       Date:  2011-09

6.  Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.

Authors:  Michael A Brehm; Waldemar J Racki; Jean Leif; Lisa Burzenski; Vishnu Hosur; Amber Wetmore; Bruce Gott; Mary Herlihy; Ronald Ignotz; Raymond Dunn; Leonard D Shultz; Dale L Greiner
Journal:  Blood       Date:  2012-01-12       Impact factor: 22.113

Review 7.  Humanized mouse models of genetic immune disorders and hematological malignancies.

Authors:  Rajeev K Tyagi; Jing Li; Justin Jacobse; Scott B Snapper; Dror S Shouval; Jeremy A Goettel
Journal:  Biochem Pharmacol       Date:  2019-10-18       Impact factor: 5.858

8.  Genetics of susceptibility to radiation-induced apoptosis in colon: two loci on chromosomes 9 and 16.

Authors:  N Mori; T van Wezel; M van der Valk; J Yamate; S Sakuma; M Okumoto; P Demant
Journal:  Mamm Genome       Date:  1998-05       Impact factor: 2.957

9.  Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Authors:  T Blunt; D Gell; M Fox; G E Taccioli; A R Lehmann; S P Jackson; P A Jeggo
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

Review 10.  Use of humanized severe combined immunodeficient mice for human vaccine development.

Authors:  Gloria C Koo; Aisha Hasan; Richard J O'Reilly
Journal:  Expert Rev Vaccines       Date:  2009-01       Impact factor: 5.217
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