Literature DB >> 7479337

Pituitary adenylate cyclase-activating peptide stimulates neurite growth in PC12 cells.

A Hernandez1, B Kimball, G Romanchuk, M W Mulholland.   

Abstract

The ability of PACAP-38 to stimulate morphological development was studied using rat pheochromocytoma PC12 cells. PACAP-38 produced concentration-dependent increases in percentage of cells exhibiting neurite extension. Similar increases were produced by forskolin (28 +/- 2% at 96 h) and 8-bromo cAMP (30 +/- 2%). Vasoactive intestinal peptide and alpha-calcitonin gene-related peptide were without effect. PACAP-38 produced significant increases in PC12 cell cAMP content and inositol phosphate turnover. Intracellular [Ca2+] increased from 169 +/- 14 nM to 560 +/- 58 nM in response to 1 microM PACAP-38. PACAP-stimulated neurite outgrowth was abolished by RpcAMPS, an inhibitor of cAMP-dependent kinases but was unaffected by the protein kinase C antagonist H7.

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Year:  1995        PMID： 7479337     DOI： 10.1016/0196-9781(95)00059-s

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  14 in total

1.  Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1.

Authors:  Alexander M Stessin; Jonathan H Zippin; Margarita Kamenetsky; Kenneth C Hess; Jochen Buck; Lonny R Levin
Journal:  J Biol Chem       Date:  2006-04-20       Impact factor: 5.157

2.  Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation.

Authors:  Eun Hye Lee; Seon Sook Kim; Seul Lee; Kwan-Hyuck Baek; Su Ryeon Seo
Journal:  J Biol Chem       Date:  2015-07-08       Impact factor: 5.157

3.  Neuroprotection by endogenous and exogenous PACAP following stroke.

Authors:  Yun Chen; Babru Samal; Carol R Hamelink; Charlie C Xiang; Yong Chen; Mei Chen; David Vaudry; Michael J Brownstein; John M Hallenbeck; Lee E Eiden
Journal:  Regul Pept       Date:  2006-10-04

4.  Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development.

Authors:  D Vaudry; B J Gonzalez; M Basille; A Fournier; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

5.  Signaling cascades involved in neuroprotection by subpicomolar pituitary adenylate cyclase-activating polypeptide 38.

Authors:  Min Li; Csaba David; Toshiteru Kikuta; Aniko Somogyvari-Vigh; Akira Arimura
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

6.  Pituitary adenylate cyclase-activating polypeptide (PACAP-38) protects cerebellar granule neurons from apoptosis by activating the mitogen-activated protein kinase (MAP kinase) pathway.

Authors:  M Villalba; J Bockaert; L Journot
Journal:  J Neurosci       Date:  1997-01-01       Impact factor: 6.167

7.  Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes.

Authors:  Adriano Sebollela; Léo Freitas-Corrêa; Fábio F Oliveira; Camila T Mendes; Ana Paula Wasilewska-Sampaio; Juliana Camacho-Pereira; Antonio Galina; Helena Brentani; Fabio Passetti; Fernanda G De Felice; Emmanuel Dias-Neto; Sérgio T Ferreira
Journal:  Neurotox Res       Date:  2009-12-01       Impact factor: 3.911

8.  Functional whole-genome analysis identifies Polo-like kinase 2 and poliovirus receptor as essential for neuronal differentiation upstream of the negative regulator alphaB-crystallin.

Authors:  Cristina Draghetti; Catherine Salvat; Francisca Zanoguera; Marie-Laure Curchod; Chloé Vignaud; Helene Peixoto; Alessandro Di Cara; David Fischer; Mohanraj Dhanabal; Goutopoulos Andreas; Hadi Abderrahim; Christian Rommel; Montserrat Camps
Journal:  J Biol Chem       Date:  2009-08-21       Impact factor: 5.157

9.  Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation.

Authors:  Geng-Xian Shi; Ling Jin; Douglas A Andres
Journal:  Mol Cell Biol       Date:  2008-06-09       Impact factor: 4.272

10.  Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation.

Authors:  Tatiana Fila; Stefania Trazzi; Christophe Crochemore; Renata Bartesaghi; Elisabetta Ciani
Journal:  J Biol Chem       Date:  2009-04-03       Impact factor: 5.157
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