Literature DB >> 7478540

Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.

K Mossie1, B Jallal, F Alves, I Sures, G D Plowman, A Ullrich.   

Abstract

Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon tissues, expression varied remarkably in colon carcinoma-derived cell lines. CCK-4 cDNA encodes a chicken KLG-related, 1071 amino acid-long transmembrane glycoprotein containing several genetic alterations within the RTK consensus sequences. These define CCK-4 as a catalytically inactive member of the RTK family of proteins and, in analogy to HER3, suggest a potentially tumor-characteristic role as a signal amplifier or modulator for an as yet unidentified kinase-competent partner.

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Year:  1995        PMID： 7478540

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  58 in total

1.  The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing.

Authors:  H Waterman; I Alroy; S Strano; R Seger; Y Yarden
Journal:  EMBO J       Date:  1999-06-15       Impact factor: 11.598

2.  Functional co-operation between the subunits in heterodimeric platelet-derived growth factor receptor complexes.

Authors:  M Emaduddin; S Ekman; L Rönnstrand; C H Heldin
Journal:  Biochem J       Date:  1999-08-01       Impact factor: 3.857

3.  Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family.

Authors:  R M Katso; R B Russell; T S Ganesan
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

4.  The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells.

Authors:  Hye-Won Na; Won-Sik Shin; Andreas Ludwig; Seung-Taek Lee
Journal:  J Biol Chem       Date:  2012-06-04       Impact factor: 5.157

5.  Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.

Authors:  Vladislav S Golubkov; Alexander E Aleshin; Alex Y Strongin
Journal:  J Biol Chem       Date:  2011-04-25       Impact factor: 5.157

6.  Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation.

Authors:  Rosana D Meyer; Amrik Singh; Fredric Majnoun; Catharina Latz; Kameran Lashkari; Nader Rahimi
Journal:  Oncogene       Date:  2004-07-15       Impact factor: 9.867

7.  Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signalling.

Authors:  Francesca Puppo; Virginie Thomé; Anne-Catherine Lhoumeau; Marie Cibois; Akanksha Gangar; Frédérique Lembo; Edwige Belotti; Sylvie Marchetto; Patrick Lécine; Thomas Prébet; Michael Sebbagh; Won-Sik Shin; Seung-Taek Lee; Laurent Kodjabachian; Jean-Paul Borg
Journal:  EMBO Rep       Date:  2010-12-03       Impact factor: 8.807

8.  The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.

Authors:  Derrick M Glasco; Vinoth Sittaramane; Whitney Bryant; Bernd Fritzsch; Anagha Sawant; Anju Paudyal; Michelle Stewart; Philipp Andre; Gonçalo Cadete Vilhais-Neto; Yingzi Yang; Mi-Ryoung Song; Jennifer N Murdoch; Anand Chandrasekhar
Journal:  Dev Biol       Date:  2012-07-04       Impact factor: 3.582

9.  18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression.

Authors:  Orit Jacobson; Ido D Weiss; Lu Wang; Zhe Wang; Xiangyu Yang; Andrew Dewhurst; Ying Ma; Guizhi Zhu; Gang Niu; Dale O Kiesewetter; Neil Vasdev; Steven H Liang; Xiaoyuan Chen
Journal:  J Nucl Med       Date:  2015-08-27       Impact factor: 10.057

10.  Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7).

Authors:  Vladislav S Golubkov; Alex Y Strongin
Journal:  J Biol Chem       Date:  2012-10-24       Impact factor: 5.157
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