| Literature DB >> 7477341 |
Abstract
Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants. Whereas human NK cell class I receptors consist of immunoglobulin domains, their mouse counterparts resemble C-type lectins. This difference may reflect the receptors' diverse and rapidly evolving class I ligands.Entities:
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Year: 1995 PMID: 7477341 DOI: 10.1038/378245a0
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962