| Literature DB >> 7477317 |
W S Talbot1, B Trevarrow, M E Halpern, A E Melby, G Farr, J H Postlethwait, T Jowett, C B Kimmel, D Kimelman.
Abstract
The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.Entities:
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Year: 1995 PMID： 7477317 DOI： 10.1038/378150a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962