Literature DB >> 7477282

Structure of the fibre-forming protein pilin at 2.6 A resolution.

H E Parge1, K T Forest, M J Hickey, D A Christensen, E D Getzoff, J A Tainer.   

Abstract

The crystallographic structure of Neisseria gonorrhoeae pilin, which assembles into the multifunctional pilus adhesion and virulence factor, reveals an alpha-beta roll fold with a striking 85 A alpha-helical spine and an O-linked disaccharide. Key residues stabilize interactions that allow sequence hypervariability, responsible for pilin's celebrated antigenic variation, within disulphide region beta-strands and connections. Pilin surface shape, hydrophobicity and sequence variation constrain pilus assembly to the packing of flat subunit faces against alpha 1 helices. Helical fibre assembly is postulated to form a core of coiled alpha 1 helices banded by beta-sheet, leaving carbohydrate and hypervariable sequence regions exposed to solvent.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7477282     DOI： 10.1038/378032a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  164 in total

1.  Components and dynamics of fiber formation define a ubiquitous biogenesis pathway for bacterial pili.

Authors:  M Wolfgang; J P van Putten; S F Hayes; D Dorward; M Koomey
Journal:  EMBO J       Date:  2000-12-01       Impact factor: 11.598

2.  XpsG, the major pseudopilin in Xanthomonas campestris pv. campestris, forms a pilus-like structure between cytoplasmic and outer membranes.

Authors:  Nien-Tai Hu; Wei-Ming Leu; Meng-Shiunn Lee; Avon Chen; Shu-Chung Chen; Yu-Ling Song; Ling-Yun Chen
Journal:  Biochem J       Date:  2002-07-01       Impact factor: 3.857

3.  Macromolecular organization of the Yersinia pestis capsular F1 antigen: insights from time-of-flight mass spectrometry.

Authors:  M A Tito; J Miller; K F Griffin; E D Williamson; R W Titball; C V Robinson
Journal:  Protein Sci       Date:  2001-11       Impact factor: 6.725

4.  Three-dimensional structure of the Neisseria meningitidis secretin PilQ determined from negative-stain transmission electron microscopy.

Authors:  Richard F Collins; Robert C Ford; Ashraf Kitmitto; Ranveig O Olsen; Tone Tønjum; Jeremy P Derrick
Journal:  J Bacteriol       Date:  2003-04       Impact factor: 3.490

5.  Single pilus motor forces exceed 100 pN.

Authors:  Berenike Maier; Laura Potter; Magdalene So; Cynthia D Long; Hank S Seifert; Michael P Sheetz
Journal:  Proc Natl Acad Sci U S A       Date:  2002-11-22       Impact factor: 11.205

6.  A force-dependent switch reverses type IV pilus retraction.

Authors:  Berenike Maier; Michael Koomey; Michael P Sheetz
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-15       Impact factor: 11.205

Review 7.  Phase and antigenic variation in bacteria.

Authors:  Marjan W van der Woude; Andreas J Bäumler
Journal:  Clin Microbiol Rev       Date:  2004-07       Impact factor: 26.132

8.  Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins.

Authors:  Philippe C Morand; Emmanuelle Bille; Sandrine Morelle; Emmanuel Eugène; Jean-Luc Beretti; Matthew Wolfgang; Thomas F Meyer; Michael Koomey; Xavier Nassif
Journal:  EMBO J       Date:  2004-04-22       Impact factor: 11.598

Review 9.  Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function.

Authors:  David G Thanassi; James B Bliska; Peter J Christie
Journal:  FEMS Microbiol Rev       Date:  2012-05-24       Impact factor: 16.408

Review 10.  Pathogenic Neisseria--interplay between pro- and eukaryotic worlds.

Authors:  T F Meyer
Journal:  Folia Microbiol (Praha)       Date:  1998       Impact factor: 2.099
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.