Literature DB >> 747657

Post-translational regulation of lipoprotein lipase activity in adipose tissue.

P Ashby, D P Bennett, I M Spencer, D S Robinson.   

Abstract

Changes in adipose-tissue lipoprotein lipase activity that are independent of protein synthesis were investigated in an incubation system in vitro. Under appropriate conditions at 25 degrees C a progressive increase in the enzyme activity occurs that is energy-dependent. Part of the enzyme is rapidly inactivated when the tissue is incubated with adrenaline or adrenaline plus theophylline. The mechanism of this inactivation appears to be distinct from, and to follow, the activation of the enzyme. A hypothesis is presented to account for the results in terms of an activation of the enzyme during obligatory post-translational processing and a catecholamine-regulated inactivation of the enzyme as an alternative to secretion from the adipocyte.

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Year:  1978        PMID： 747657      PMCID： PMC1186310          DOI： 10.1042/bj1760865

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  30 in total

1.  An enzymic method for the estimation of glycerol in blood and its use to determine the effect of noradrenaline on the concentration of glycerol in blood.

Authors:  J H HAGEN; P B HAGEN
Journal:  Can J Biochem Physiol       Date:  1962-08

Review 2.  The role of organelles in the chemical modification of the primary translation products of secretory proteins.

Authors:  P N Campbell; G Blobel
Journal:  FEBS Lett       Date:  1976-12-31       Impact factor: 4.124

3.  Purification and characterization of lipoprotein lipase from pig adipose tissue.

Authors:  A Bensadoun; C Ehnholm; D Steinberg; W V Brown
Journal:  J Biol Chem       Date:  1974-04-10       Impact factor: 5.157

4.  Stimulation by growth hormone and dexamethasone of labeled cyclic adenosine 3',5'-monophosphate accumulation by white fat cells.

Authors:  J Moskowitz; J N Fain
Journal:  J Biol Chem       Date:  1970-03-10       Impact factor: 5.157

5.  Lipoprotein lipase from bovine milk. Isolation procedure, chemical characterization, and molecular weight analysis.

Authors:  P H Iverius; A M Ostlund-Lindqvist
Journal:  J Biol Chem       Date:  1976-12-25       Impact factor: 5.157

Review 6.  Regulation of fatty-acid synthesis in higher animals.

Authors:  S Numa
Journal:  Ergeb Physiol       Date:  1974

7.  The heterogeneity of the lipoprotein lipase of rat epididymal adipose tissue.

Authors:  P Ashby; A M Tolson; D S Robinson
Journal:  Biochem J       Date:  1978-05-01       Impact factor: 3.857

8.  Stimulatory action of cycloheximide on glucose metabolism in the rat epididymal fat pad.

Authors:  J A García-Sáinz; E Piña; V Chagoya de Sánchez
Journal:  J Lipid Res       Date:  1977-01       Impact factor: 5.922

9.  Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine.

Authors:  R W Butcher; R J Ho; H C Meng; E W Sutherland
Journal:  J Biol Chem       Date:  1965-11       Impact factor: 5.157

10.  Hormone-sensitive lipase of adipose tissue.

Authors:  D Steinberg; J C Khoo
Journal:  Fed Proc       Date:  1977-06
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  14 in total

1.  Effects of caffeine on lipoprotein lipase gene expression during the adipocyte differentiation process.

Authors:  C Couturier; B Janvier; D Girlich; G Béréziat; M Andréani-Mangeney
Journal:  Lipids       Date:  1998-05       Impact factor: 1.880

2.  Failure of the nonselective beta-blocker propranolol to affect lipoprotein lipase gene expression in the rat.

Authors:  I Gouni-Berthold; K Oka; H K Berthold; L Chan
Journal:  Lipids       Date:  1997-09       Impact factor: 1.880

3.  The lipoprotein lipase of white adipose tissue. Changes in the adipocyte cell-surface content of enzyme in response to extracellular effectors in vitro.

Authors:  A A Al-Jafari; A Cryer
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857

Review 4.  The effects of diuretics and adrenergic-blocking agents on plasma lipids.

Authors:  J J Rohlfing; J D Brunzell
Journal:  West J Med       Date:  1986-08

5.  Evidence against the involvement of cyclic GMP in the insulin-stimulation of lipoprotein lipase activity in fat cells.

Authors:  A M Bourdeaux; Y Giudicelli; M C Rebourcet; J Nordmann; R Nordmann
Journal:  Experientia       Date:  1980-08-15

6.  Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue.

Authors:  J M Ong; P A Kern
Journal:  J Clin Invest       Date:  1989-07       Impact factor: 14.808

7.  Purification and characterization of rat adipose tissue lipoprotein lipase.

Authors:  S M Parkin; B K Speake; D S Robinson
Journal:  Biochem J       Date:  1982-12-01       Impact factor: 3.857

8.  The activities of lipoprotein lipase and of enzymes involved in triacylglycerol synthesis in rat adipose tissue. Effects of starvation, dietary modification and of corticotropin injection.

Authors:  N Lawson; A D Pollard; R J Jennings; M I Gurr; D N Brindley
Journal:  Biochem J       Date:  1981-11-15       Impact factor: 3.857

9.  Regulation of lipoprotein lipase synthesis in 3T3-L1 adipocytes by cachectin. Further proof for identity with tumour necrosis factor.

Authors:  S R Price; T Olivecrona; P H Pekala
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857

10.  Lipoprotein lipase activity of rat cardiac muscle. Changes in the enzyme activity during incubations of isolated cardiac-muscle cells in vitro.

Authors:  P Chohan; A Cryer
Journal:  Biochem J       Date:  1980-03-15       Impact factor: 3.857
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