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Literature DB >> 7474897

Trimethylaminuria, fish odour syndrome: a new method of detection and response to treatment with metronidazole.

E Treacy¹, D Johnson, J J Pitt, D M Danks.

Abstract

Trimethylaminuria is an autosomal recessive disorder involving deficient N-oxidation of the dietary-derived amine trimethylamine (TMA). TMA, a volatile tertiary amine, accumulates and is excreted in urine of patients with deficient TMA oxidase activity. Treatment strategies for this condition are limited. We report a new stable-isotope dilution method for rapid sequential analysis of TMA concentrations and the clinical and biochemical response to treatment with metronidazole.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1995 PMID： 7474897 DOI： 10.1007/bf00710420

Source DB: PubMed Journal: J Inherit Metab Dis ISSN： 0141-8955 Impact factor: 4.982

10 in total

1. Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.

Authors: N Lomri; Q Gu; J R Cashman
Journal: Proc Natl Acad Sci U S A Date: 1992-03-01 Impact factor: 11.205

2. The use of metronidazole in management of methylmalonic and propionic acidaemias.

Authors: G N Thompson; R A Chalmers; J H Walter; J L Bresson; S L Lyonnet; P J Reed; J M Saudubray; J V Leonard; D Halliday
Journal: Eur J Pediatr Date: 1990-08 Impact factor: 3.183

3. Trimethylaminuria: diet does not always control the fishy odor.

Authors: D M Danks; J Hammond; P Schlesinger; K Faull; D Burke; B Halpern
Journal: N Engl J Med Date: 1976-10-21 Impact factor: 91.245

4. An improved gas--liquid chromatographic method for analysis of trimethylamine in urine.

Authors: P Schlesinger
Journal: Anal Biochem Date: 1979-04-15 Impact factor: 3.365

5. Trimethylamine N-oxide synthesis: a human variant.

Authors: T Higgins; S Chaykin; K B Hammond; J R Humbert
Journal: Biochem Med Date: 1972-08

6. Trimethylaminuria ('fish-odour syndrome'): a study of an affected family.

Authors: M Al-Waiz; R Ayesh; S C Mitchell; J R Idle; R L Smith
Journal: Clin Sci (Lond) Date: 1988-03 Impact factor: 6.124

7. The fish odour syndrome: biochemical, familial, and clinical aspects.

Authors: R Ayesh; S C Mitchell; A Zhang; R L Smith
Journal: BMJ Date: 1993-09-11

8. The fish odor syndrome. Trimethylaminuria.

Authors: E D Shelley; W B Shelley
Journal: JAMA Date: 1984-01-13 Impact factor: 56.272

Review 9. Trimethylaminuria in a girl with Prader-Willi syndrome and del(15)(q11q13).

Authors: H Chen; F Aiello
Journal: Am J Med Genet Date: 1993-02-01

10. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.

Authors: C T Dolphin; E A Shephard; S Povey; R L Smith; I R Phillips
Journal: Biochem J Date: 1992-10-01 Impact factor: 3.857

10 in total

15 in total

Trimethylaminuria, fish odour syndrome: a new method of detection and response to treatment with metronidazole.

1. Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.

2. The use of metronidazole in management of methylmalonic and propionic acidaemias.

3. Trimethylaminuria: diet does not always control the fishy odor.

4. An improved gas--liquid chromatographic method for analysis of trimethylamine in urine.

5. Trimethylamine N-oxide synthesis: a human variant.

6. Trimethylaminuria ('fish-odour syndrome'): a study of an affected family.

7. The fish odour syndrome: biochemical, familial, and clinical aspects.

8. The fish odor syndrome. Trimethylaminuria.

Review 9. Trimethylaminuria in a girl with Prader-Willi syndrome and del(15)(q11q13).

10. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family.

1. Clinical utility gene card for: trimethylaminuria.

2. A pilot study of the effect of (e, e)-2, 4-undecadienal on the offensive odour of trimethylamine.

3. Riboflavin-responsive trimethylaminuria in a patient with homocystinuria on betaine therapy.

4. Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae.

5. Trimethylaminuria: causes and diagnosis of a socially distressing condition.

6. Diagnosis and management of trimethylaminuria (FMO3 deficiency) in children.

7. Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria.

8. Aerococcus urinae: a possible reason for malodorous urine in otherwise healthy children.

9. Trimethylaminuria.

Review 10. A review of trimethylaminuria: (fish odor syndrome).