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Literature DB >> 7474153

A point mutation in the VP4 coding sequence of coxsackievirus B4 influences virulence.

Abstract

In analyzing the molecular determinants of virulence of coxsackievirus B4, chimeric viruses were constructed from avirulent and virulent viruses. The vCB424 recombinant contained a single nucleotide substitution on an avirulent genetic background, resulting in replacement of Ser-16 of VP4 with Arg-16. Mice infected with vCB424 displayed an intermediate phenotype.

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Year: 1995 PMID： 7474153 PMCID： PMC189653

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

20 in total

1. A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.

Authors: J M Tatem; C Weeks-Levy; A Georgiu; S J DiMichele; E J Gorgacz; V R Racaniello; F R Cano; S J Mento
Journal: J Virol Date: 1992-05 Impact factor: 5.103

2. Immunomodulation of encephalomyocarditis virus-induced disease in A/J mice.

Authors: M T Barger; J E Craighead
Journal: J Virol Date: 1991-05 Impact factor: 5.103

3. The 5' noncoding region of the type 2 poliovirus vaccine strain contains determinants of attenuation and temperature sensitivity.

Authors: A J Macadam; S R Pollard; G Ferguson; G Dunn; R Skuce; J W Almond; P D Minor
Journal: Virology Date: 1991-04 Impact factor: 3.616

4. Identification of a single amino acid residue in the capsid protein VP1 of coxsackievirus B4 that determines the virulent phenotype.

Authors: M Caggana; P Chan; A Ramsingh
Journal: J Virol Date: 1993-08 Impact factor: 5.103

5. A mutation in VP4 defines a new step in the late stages of cell entry by poliovirus.

Authors: N Moscufo; A G Yafal; A Rogove; J Hogle; M Chow
Journal: J Virol Date: 1993-08 Impact factor: 5.103

6. An infectious cDNA copy of the genome of a non-cardiovirulent coxsackievirus B3 strain: its complete sequence analysis and comparison to the genomes of cardiovirulent coxsackieviruses.

Authors: N M Chapman; Z Tu; S Tracy; C J Gauntt
Journal: Arch Virol Date: 1994 Impact factor: 2.574

7. Identification of candidate sequences that determine virulence in Coxsackievirus B4.

Authors: A Ramsingh; H Araki; S Bryant; A Hixson
Journal: Virus Res Date: 1992-05 Impact factor: 3.303

8. Mouse neurovirulence determinants of poliovirus type 1 strain LS-a map to the coding regions of capsid protein VP1 and proteinase 2Apro.

Authors: H H Lu; C F Yang; A D Murdin; M H Klein; J J Harber; O M Kew; E Wimmer
Journal: J Virol Date: 1994-11 Impact factor: 5.103

9. Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell.

Authors: T Couderc; J Hogle; H Le Blay; F Horaud; B Blondel
Journal: J Virol Date: 1993-07 Impact factor: 5.103

10. Attenuation of a reactivated cardiovirulent coxsackievirus B3: The 5'-nontranslated region does not contain major attenuation determinants.

Authors: H Y Zhang; G E Yousef; L Cunningham; N W Blake; X OuYang; T A Bayston; R Kandolf; L C Archard
Journal: J Med Virol Date: 1993-10 Impact factor: 2.327

14 in total

1. Mapping the genetic determinants of pathogenicity and plaque phenotype in swine vesicular disease virus.

Authors: T Kanno; D Mackay; T Inoue; G Wilsden; M Yamakawa; R Yamazoe; S Yamaguchi; J Shirai; P Kitching; Y Murakami
Journal: J Virol Date: 1999-04 Impact factor: 5.103

2. Differential recruitment of B and T cells in coxsackievirus B4-induced pancreatitis is influenced by a capsid protein.

Authors: A I Ramsingh; W T Lee; D N Collins; L E Armstrong
Journal: J Virol Date: 1997-11 Impact factor: 5.103

Review 3. Molecular typing of enteroviruses: current status and future requirements. The European Union Concerted Action on Virus Meningitis and Encephalitis.

Authors: P Muir; U Kämmerer; K Korn; M N Mulders; T Pöyry; B Weissbrich; R Kandolf; G M Cleator; A M van Loon
Journal: Clin Microbiol Rev Date: 1998-01 Impact factor: 26.132

4. Genomic determinants of cardiovirulence in coxsackievirus B3 clinical isolates: localization to the 5' nontranslated region.

Authors: J J Dunn; N M Chapman; S Tracy; J R Romero
Journal: J Virol Date: 2000-05 Impact factor: 5.103

5. Coxsackievirus B3-induced myocarditis. Characterization of stable attenuated variants that protect against infection with the cardiovirulent wild-type strain.

Authors: H Zhang; P Morgan-Capner; N Latif; Y A Pandolfino; W Fan; M J Dunn; L C Archard
Journal: Am J Pathol Date: 1997-06 Impact factor: 4.307

6. The crystal structure of a coxsackievirus B3-RD variant and a refined 9-angstrom cryo-electron microscopy reconstruction of the virus complexed with decay-accelerating factor (DAF) provide a new footprint of DAF on the virus surface.

Authors: Joshua D Yoder; Javier O Cifuente; Jieyan Pan; Jeffrey M Bergelson; Susan Hafenstein
Journal: J Virol Date: 2012-09-12 Impact factor: 5.103

7. Attenuating mutations in coxsackievirus B3 map to a conformational epitope that comprises the puff region of VP2 and the knob of VP3.

Authors: E Stadnick; M Dan; A Sadeghi; J K Chantler
Journal: J Virol Date: 2004-12 Impact factor: 5.103