Literature DB >> 7473590

1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist.

P D Williams1, B V Clineschmidt, J M Erb, R M Freidinger, M T Guidotti, E V Lis, J M Pawluczyk, D J Pettibone, D R Reiss, D F Veber.   

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Year:  1995        PMID： 7473590     DOI： 10.1021/jm00023a002

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  18 in total

1.  Pharmacologic characterization of the oxytocin receptor in human uterine smooth muscle cells.

Authors:  A Tahara; J Tsukada; Y Tomura; K i Wada; T Kusayama; N Ishii; T Yatsu; W Uchida; A Tanaka
Journal:  Br J Pharmacol       Date:  2000-01       Impact factor: 8.739

2.  Identification of an extracellular segment of the oxytocin receptor providing agonist-specific binding epitopes.

Authors:  S R Hawtin; H C Howard; M Wheatley
Journal:  Biochem J       Date:  2001-03-01       Impact factor: 3.857

3.  Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b/oxytocin receptor antagonist.

Authors:  Cristiana Griffante; Andrew Green; Ornella Curcuruto; Carl P Haslam; Bryony A Dickinson; Roberto Arban
Journal:  Br J Pharmacol       Date:  2005-11       Impact factor: 8.739

4.  The 3D structure of the binding pocket of the human oxytocin receptor for benzoxazine antagonists, determined by molecular docking, scoring functions and 3D-QSAR methods.

Authors:  Balázs Jójárt; Tamás A Martinek; Arpád Márki
Journal:  J Comput Aided Mol Des       Date:  2005-05       Impact factor: 3.686

5.  Possible dynamic anchor points in a benzoxazinone derivative-human oxytocin receptor system--a molecular docking and dynamics calculation.

Authors:  Balázs Jójárt; Arpád Márki
Journal:  J Mol Model       Date:  2006-05-05       Impact factor: 1.810

6.  Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.

Authors:  Derek B J Bone; Jaroslawna Meister; Jonas R Knudsen; Diptadip Dattaroy; Amanda Cohen; Regina Lee; Huiyan Lu; Daniel Metzger; Thomas E Jensen; Jürgen Wess
Journal:  Diabetes       Date:  2019-04-01       Impact factor: 9.461

7.  Anxiolytic-like activity of oxytocin in male mice: behavioral and autonomic evidence, therapeutic implications.

Authors:  Robert H Ring; Jessica E Malberg; Lisa Potestio; Julia Ping; Steve Boikess; Bin Luo; Lee E Schechter; Stacey Rizzo; Zia Rahman; Sharon Rosenzweig-Lipson
Journal:  Psychopharmacology (Berl)       Date:  2006-01-18       Impact factor: 4.530

8.  Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors.

Authors:  Aaron L Smith; Sara M Freeman; Jeffery S Stehouwer; Kiyoshi Inoue; Ronald J Voll; Larry J Young; Mark M Goodman
Journal:  Bioorg Med Chem       Date:  2012-02-25       Impact factor: 3.641

9.  Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist.

Authors:  C Serradeil-Le Gal; C Lacour; G Valette; G Garcia; L Foulon; G Galindo; L Bankir; B Pouzet; G Guillon; C Barberis; D Chicot; S Jard; P Vilain; C Garcia; E Marty; D Raufaste; G Brossard; D Nisato; J P Maffrand; G Le Fur
Journal:  J Clin Invest       Date:  1996-12-15       Impact factor: 14.808

Review 10.  REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.

Authors:  Cedric Viero; Izumi Shibuya; Naoki Kitamura; Alexei Verkhratsky; Hiroaki Fujihara; Akiko Katoh; Yoichi Ueta; Hans H Zingg; Alexandr Chvatal; Eva Sykova; Govindan Dayanithi
Journal:  CNS Neurosci Ther       Date:  2010-07-07       Impact factor: 5.243
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