Literature DB >> 7471318

Comparative toxicity of detorubicin and doxorubicin, free and DNA-bound, for hemopoietic stem cells.

M Huybrechts, A Trouet.   

Abstract

We compared the toxicity of detorubicin (DET) and of doxorubicin (DOX) on the hematopoietic stem cells in C57BL6J mice by means of the CFUS and CFUC assays. On an equimolar basis DET appears to be less toxic than DOX for both the pluripotent stem cells and the granulocytic progenitor cells. Moreover, the administration of these anthracyclines as DNA complexes leads to a decreased toxicity to the pluripotent stem cells, while no such attenuated toxic effect is observed in committed stem cells.

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Year:  1980        PMID： 7471318     DOI： 10.1007/bf00435408

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  10 in total

1.  A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.

Authors:  J E TILL; E A McCULLOCH
Journal:  Radiat Res       Date:  1961-02       Impact factor: 2.841

2.  [Preparation and experimental antitumor activity of a new semi-synthetic antibiotic: 14-diethoxyacetoxy daunorubicin (R.P. 33 921)].

Authors:  R Maral; J B Ducep; D Farge; G Ponsinet; D Reisdorf
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1978-02-06

3.  Chemotherapy through lysosomes with a DNA-daunorubicin complex.

Authors:  A Trouet; D Deprez-de Campeneere; C De Duve
Journal:  Nat New Biol       Date:  1972-09-27

4.  Survival of hematopoietic and leukemic colony-forming cells in vivo following the administration of daunorubicin or adriamycin.

Authors:  A Razek; F Valeriote; T Vietti
Journal:  Cancer Res       Date:  1972-07       Impact factor: 12.701

5.  Growth of stem cell concentration in diffusion chambers (DC).

Authors:  P Quesenberry; E Niskanen; M Symann; D Howard; M Ryan; J Halpern; F Stohlman
Journal:  Cell Tissue Kinet       Date:  1974-07

6.  A survey of the anthracycline derivatives in hematology.

Authors:  C Jacquillat; M Weil; M F Auclerc; J Maral; G Schaison; M Boiron; J Bernard
Journal:  Cancer Chemother Pharmacol       Date:  1979       Impact factor: 3.333

7.  The diffusion chamber technique as an in vivo assay in mice for the effectiveness of antitumor agents.

Authors:  M Huybrechts; M Symann; A Troulet
Journal:  Scand J Haematol       Date:  1979-09

8.  Effect of endotoxin on granulopoiesis and colony-stimulating factor.

Authors:  P Quesenberry; A Morley; F Stohlman; K Rickard; D Howard; M Smith
Journal:  N Engl J Med       Date:  1972-02-03       Impact factor: 91.245

9.  Pharmacokinetic, toxicologic, and chemotherapeutic properties of detorubicin in mice: a comparative study with daunorubicin and adriamycin.

Authors:  D Deprez-de Campeneere; R Baurain; A Trouet
Journal:  Cancer Treat Rep       Date:  1979-05

10.  Effects of daunorubicin and doxorubicin, free and associated with DNA, on hemopoietic stem cells.

Authors:  M Huybrechts; M Symann; A Trouet
Journal:  Cancer Res       Date:  1979-09       Impact factor: 12.701
  10 in total

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