Literature DB >> 7470766

Investigation of the antifibrillatory activity of some anticonvulsant gamma-aminobutyric acid-transaminase inhibitors in the rabbit isolated heart: comparison with phenytoin and mexiletine.

A A Almotrefi, J B Baker.   

Abstract

1 The electrical stimulation and ventricular fibrillation thresholds were measured in the Langendorff-perfused rabbit heart by application of rectangular impulses of 3 ms duration and increasing current at frequencies of 4 and 20 Hz respectively. 2 Perfusion with either phenytoin or mexiletine produced significant dose-dependent increases in both thresholds. 3 Perfusion with four anticonvulsant inhibitors of gamma-aminobutyric acid (GABA)-transaminase, aminooxyacetic acid, gamma-acetylenic GABA, gamma-vinyl GABA and sodium valproate, up to a concentration of 20 microgram/ml, had no significant effect on either threshold. 4 The results suggest that these compounds, unlike phenytoin and mexiletine, are devoid of antifibrillatory activity.

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Year:  1980        PMID： 7470766      PMCID： PMC2044442          DOI： 10.1111/j.1476-5381.1980.tb10984.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

1.  Anticonvulsant activity of aminooxyacetic acid on convulsions induced by thiosemicarbazide.

Authors:  Y Murakami; M Abe; K Murakami
Journal:  J Neurochem       Date:  1976-03       Impact factor: 5.372

2.  The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

Authors:  M J Jung; B Lippert; B W Metcalf; P J Schechter; P Böhlen; A Sjoerdsma
Journal:  J Neurochem       Date:  1977-04       Impact factor: 5.372

3.  Catalytic inhibitors of GABA-transaminase as anticonvulsants in baboons with photosensitive epilepsy [proceedings].

Authors:  R W Horton; B S Meldrum
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

4.  Effect of sodium n-dipropylacetate on audiogenic seizures and brain -aminobutyric acid level.

Authors:  S Simler; L Ciesielski; M Maitre; H Randrianarisoa; P Mandel
Journal:  Biochem Pharmacol       Date:  1973-07-15       Impact factor: 5.858

5.  Treatment of ventricular arrhythmias with mexiletine (Kö 1173).

Authors:  R G Talbot; J Nimmo; D G Julian; R A Clark; J M Neilson; L F Prescott
Journal:  Lancet       Date:  1973-08-25       Impact factor: 79.321

6.  Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors.

Authors:  P J Schechter; Y Tranier; M J Jung; P Böhlen
Journal:  Eur J Pharmacol       Date:  1977-10-15       Impact factor: 4.432

7.  Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase.

Authors:  P J Schechter; Y Tranier; M J Jung; A Sjoerdsma
Journal:  J Pharmacol Exp Ther       Date:  1977-06       Impact factor: 4.030

8.  gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice.

Authors:  M J Jung; B Lippert; B W Metcalf; P Böhlen; P J Schechter
Journal:  J Neurochem       Date:  1977-11       Impact factor: 5.372

9.  Disposition of sodium valproate in epileptic patients.

Authors:  E Perucca; G Gatti; G M Frigo; A Crema; S Calzetti; D Visintini
Journal:  Br J Clin Pharmacol       Date:  1978-06       Impact factor: 4.335

10.  The effect of Kö 1173, a new anticonvulsant agent on experimental cardiac arrhythmias.

Authors:  J D Allen; J M Ekue; R G Shanks; S A Zaidi
Journal:  Br J Pharmacol       Date:  1972-08       Impact factor: 8.739
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  1 in total

1.  Antifibrillatory efficacy of encainide, loracainide and ORG 6001 compared with lignocaine in isolated hearts of rabbits and guinea-pigs.

Authors:  A A Almotrefi; J B Baker
Journal:  Br J Pharmacol       Date:  1981-06       Impact factor: 8.739
  1 in total

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