Literature DB >> 7470046

Secretion granules of transplantable pancreatic acinar carcinoma of rat.

J K Reddy, M K Reddy, L J Hansen, S A Qureshi.   

Abstract

Secretion granules of the rat transplantable pancreatic acinar carcinoma and of normal rat pancreas were isolated by differential centrifugation. Analysis of the granule content by sodium dodecyl sulphate/polyacrylamide-gel electrophoresis and isoelectric focusing procedures combined with specific enzyme assays indicated essential qualitative similarities between normal and neoplastic secretory proteins, suggesting retention of enzymic differentiation in this pancreatic acinar carcinoma. Accordingly, this epithelial tumor should serve as an important model for examination of regulatory mechanisms in cell differentiation and neoplasia.

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Year:  1980        PMID： 7470046      PMCID： PMC1161978          DOI： 10.1042/bj1880921

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  On the protein composition of bovine pancreatic zymogen granules.

Authors:  L J GREENE; C H HIRS; G E PALADE
Journal:  J Biol Chem       Date:  1963-06       Impact factor: 5.157

2.  A stable starch substrate for the determination of amylase in serum and other body fluids.

Authors:  W T CARAWAY
Journal:  Am J Clin Pathol       Date:  1959-07       Impact factor: 2.493

3.  The relation of structure to enzymatic activity in ribonuclease.

Authors:  G KALNITSKY; J P HUMMEL; H RESNICK; J R CARTER; L B BARNETT; C DIERKS
Journal:  Ann N Y Acad Sci       Date:  1959-09-04       Impact factor: 5.691

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Transplantable ductal adenocarcinoma of the Syrian hamster pancreas.

Authors:  D G Scarpelli; M S Rao
Journal:  Cancer Res       Date:  1979-02       Impact factor: 12.701

6.  Concanavalin A agglutinability and surface microvilli of dissociated normal and neoplastic pancreatic acinar cells of the rat.

Authors:  J K Reddy; M S Rao; J R Warren; O T Minnick
Journal:  Exp Cell Res       Date:  1979-04       Impact factor: 3.905

7.  Subcellular fractionation of the pancreas.

Authors:  A M Tartakoff; J D Jamieson
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

8.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

9.  A specific method for serum lipase determination.

Authors:  N W Tietz; E A Fiereck
Journal:  Clin Chim Acta       Date:  1966-03       Impact factor: 3.786

10.  Establishment and characterization of primary human pancreatic carcinoma in continuous cell culture and in nude mice.

Authors:  A G Grant; D Duke; J Hermon-Taylor
Journal:  Br J Cancer       Date:  1979-02       Impact factor: 7.640
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  6 in total

1.  Isolation and characterisation of insulin secretory granules from a rat islet cell tumour.

Authors:  J C Hutton; E J Penn; M Peshavaria
Journal:  Diabetologia       Date:  1982-10       Impact factor: 10.122

2.  Comparison of secretory protein and membrane composition of secretory granules isolated from normal and neoplastic pancreatic acinar cells of rats.

Authors:  L J Hansen; M K Reddy; J K Reddy
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

3.  Analysis of the Lewisx epitope in human pancreas and pancreatic adenocarcinomas.

Authors:  H P Sinn; S A Brown; E Oberle; J S Thompson
Journal:  Int J Pancreatol       Date:  1992-04

4.  Purification and characterization of alpha-amylase from rat pancreatic acinar carcinoma. Comparison with pancreatic alpha-amylase.

Authors:  M K Reddy; G D Heda; J K Reddy
Journal:  Biochem J       Date:  1987-03-15       Impact factor: 3.857

5.  Intracellular transport and storage of secretory proteins in relation to cytodifferentiation in neoplastic pancreatic acinar cells.

Authors:  M J Becich; M Bendayan; J K Reddy
Journal:  J Cell Biol       Date:  1983-04       Impact factor: 10.539

6.  Biochemical analysis of secretory proteins synthesized by normal rat pancreas and by pancreatic acinar tumor cells.

Authors:  V Iwanij; J D Jamieson
Journal:  J Cell Biol       Date:  1982-12       Impact factor: 10.539
  6 in total

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