Family influence in the recruitment of schizophrenic research subjects.

While seeking research subjects to test the effect of hemodialysis on schizophrenia, the authors noted that the relatives of schizophrenic patients tried to involve themselves excessively in the selection process. Of 27 patients referrals meeting diagnostic criteria for schizophrenia, only one contact was initiated by the patient; the rest were initiated by family members. In more than half of the family-initiated contacts relatives attempted to become excessively involved in the patient's decision making. The authors discuss these observations in light of family theories of schizophrenia. They urge caution in selecting subjects for research that attempts to test other researchers' earlier claims which may have stimulated premature hope of improvement.