Literature DB >> 7466845

Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo.

H Kieczka, H Kappus.   

Abstract

Rat liver microsomes showed an atypical oxygen dependence of carbon tetrachloride (CCL4)-induced malondialdehyde formation with a maximum at ca. 7% O2 and a minimum at ca. 15% O2. Rats treated with CCl4 expired less ethane under high oxygen concentrations and more ethane under low oxygen concentrations. The initiation of CCl4-induced lipid peroxidation in the liver would appear to be influenced by the oxygen concentrations present in the hepatocytes.

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Year:  1980        PMID： 7466845     DOI： 10.1016/0378-4274(80)90058-2

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  8 in total

1.  Tetrachloromethane metabolism in vivo under normoxia and hypoxia. Biochemical and histopathological effects relative to alkane exhalation.

Authors:  H Dürk; C Klessen; H Frank
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

2.  Lipid peroxidation in isolated rat hepatocytes measured by ethane and n-pentane formation.

Authors:  N de Ruiter; H Ottenwälder; H Muliawan; H Kappus
Journal:  Arch Toxicol       Date:  1982-03       Impact factor: 5.153

3.  Potentiation of carbon tetrachloride hepatotoxicity by hypoxia.

Authors:  Y Shibayama
Journal:  Br J Exp Pathol       Date:  1986-12

4.  Binding of trichloromethyl radicals to lipids of the hepatic endoplasmic reticulum during tetrachloromethane metabolism.

Authors:  B Link; H Dürk; D Thiel; H Frank
Journal:  Biochem J       Date:  1984-11-01       Impact factor: 3.857

5.  Reduced glutathione protection against rat liver microsomal injury by carbon tetrachloride. Dependence on O2.

Authors:  R F Burk; K Patel; J M Lane
Journal:  Biochem J       Date:  1983-12-01       Impact factor: 3.857

6.  Relationship of oxygen and glutathione in protection against carbon tetrachloride-induced hepatic microsomal lipid peroxidation and covalent binding in the rat. Rationale for the use of hyperbaric oxygen to treat carbon tetrachloride ingestion.

Authors:  R F Burk; J M Lane; K Patel
Journal:  J Clin Invest       Date:  1984-12       Impact factor: 14.808

Review 7.  Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation.

Authors:  H Kappus; H Sies
Journal:  Experientia       Date:  1981-12-15

8.  Amelioration of CCl4 induced liver injury in swiss albino mice by antioxidant rich leaf extract of Croton bonplandianus Baill.

Authors:  Somit Dutta; Arnab Kumar Chakraborty; Priyankar Dey; Pallab Kar; Pokhraj Guha; Subhajit Sen; Anoop Kumar; Arnab Sen; Tapas Kumar Chaudhuri
Journal:  PLoS One       Date:  2018-04-30       Impact factor: 3.240
  8 in total

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