Literature DB >> 7466386

Conversion of 3T3-L1 fibroblasts to fat cells by an inhibitor of methylation: effect of 3-deazaadenosine.

P K Chiang.   

Abstract

3-Deazaadenosine, an inhibitor of methylation, increased the frequency of conversion of 3T3-L1 fibroblasts to fat cells in a dose-dependent manner. Once converted, the 3T3-L1 fat cells retained their adipose morphology and accumulated triglycerides even when 3-deazaadenosine was removed from the culture medium. 3-Deazaadenosine may perturb cellular methylation and thereby lead to an increase in the frequency of differentiation of 3T3-L1 fibroblasts to fat cells.

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Year:  1981        PMID： 7466386     DOI： 10.1126/science.7466386

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Evaluation of total plasma homocysteine in Indian newborns using heel-prick samples.

Authors:  A Radha Rama Devi; S M Naushad; Krishna C Prasad
Journal:  Indian J Pediatr       Date:  2006-06       Impact factor: 1.967

2.  Adipose cell differentiation in culture.

Authors:  G Ailhaud
Journal:  Mol Cell Biochem       Date:  1982-11-12       Impact factor: 3.396

Review 3.  Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine.

Authors:  J H Alix
Journal:  Microbiol Rev       Date:  1982-09

4.  Differentiation of myoblast cell lines and biological methylation: 3-deazaadenosine stimulates formation of multinucleated myofibers.

Authors:  S Scarpa; R Strom; A Bozzi; R R Aksamit; P S Backlund; J Chen; G L Cantoni
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

5.  (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells.

Authors:  Subhasree Roy Choudhury; Sivaprakasam Balasubramanian; Yap Ching Chew; Bingshe Han; Victor E Marquez; Richard L Eckert
Journal:  Carcinogenesis       Date:  2011-07-27       Impact factor: 4.944

6.  Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.

Authors:  Jing Tan; Xiaojing Yang; Li Zhuang; Xia Jiang; Wei Chen; Puay Leng Lee; R K Murthy Karuturi; Patrick Boon Ooi Tan; Edison T Liu; Qiang Yu
Journal:  Genes Dev       Date:  2007-04-16       Impact factor: 11.361

7.  Anti-human immunodeficiency virus 1 (HIV-1) activities of 3-deazaadenosine analogs: increased potency against 3'-azido-3'-deoxythymidine-resistant HIV-1 strains.

Authors:  D L Mayers; J A Mikovits; B Joshi; I K Hewlett; J S Estrada; A D Wolfe; G E Garcia; B P Doctor; D S Burke; R K Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1995-01-03       Impact factor: 11.205

8.  Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma.

Authors:  R M Jotte; J T Holt
Journal:  J Cell Biol       Date:  1996-10       Impact factor: 10.539
  8 in total

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