Literature DB >> 7465611

Dopamine depletion by 6-hydroxydopamine prevents conditioned taste aversion induced by methylamphetamine but not lithium chloride.

G C Wagner, R W Foltin, L S Seiden, C R Schuster.   

Abstract

Specific lesions of the central dopaminergic system produced by intraventricular injections of 6-hydroxydopamine with pargyline and desmethylimipramine pretreatment significantly attenuated conditioned taste aversions to a sweetened-condensed milk solution induced by methylamphetamine. Identically treated rats formed an aversion to the milk solution when lithium chloride was utilized. These results suggest that the methylamphetamine-induced aversion is dependent upon intact dopaminergic neurons.

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Year:  1981        PMID： 7465611     DOI： 10.1016/0091-3057(81)90107-6

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  4 in total

1.  Anatomical disassociation of amphetamine's rewarding and aversive effects: an intracranial microinjection study.

Authors:  G D Carr; N M White
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  A role for dopamine D1 receptors of the nucleus accumbens shell in conditioned taste aversion learning.

Authors:  S Fenu; V Bassareo; G Di Chiara
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

3.  Blockade of conditioned taste aversion by scopolamine and N-methyl scopolamine: associative conditioning, not amnesia.

Authors:  J L Evenden; L Lavis; S D Iversen
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 4.  Do conditioned taste aversions result from activation of emetic mechanisms?

Authors:  V L Grant
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  4 in total

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