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Literature DB >> 7464829

Effect of fasting on delta 5 desaturation activity in rat liver microsomes and HTC cells.

M J de Alaniz, I N de Gómez Dumm, R R Brenner.

Abstract

The effect of fasting on delta 5 desaturation activity in Minimal Deviation Hepatoma 7288c (HTC) cells and in rat liver microsomes was studied. When HTC cells were incubated in the absence of carbon sources in the medium (fasted cells) the conversion of [1-14C] eicosa-8,11,14-trienoic acid to arachidonic acid increased significantly compared to those cells incubated in complete medium (fed cells). This effect was also shown in rat liver microsomes of rats fasted for 12, 24 and 48 hr. Fasting produced a decrease of the amount of ethanolamine fraction in HTC cells together with a significant increase in the specific activity of the same fraction. Fasting also modified the fatty acid composition of HTC cells and rat liver microsomes. There was observed a relative increase of 18:2 omega 6 acid. The importance of the difference in fatty acid and lipid composition among fasted and fed HTC cells and rat liver microsomes on delta 5 desaturation activity was discussed.

Entities: Chemical Disease Species

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Year: 1980 PMID： 7464829 DOI： 10.1007/bf00225290

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

20 in total

1. UPTAKE OF FREE FATTY ACIDS BY EHRLICH ASCITES TUMOR CELLS.

Authors: A A SPECTOR; D STEINBERG; A TANAKA
Journal: J Biol Chem Date: 1965-03 Impact factor: 5.157

2. Specificity of 5- and 6-fatty acid desaturases in rat and fish.

Authors: R E Ninno; M A de Torrengo; J C Castuma; R R Brenner
Journal: Biochim Biophys Acta Date: 1974-08-22

3. Effect of arachidonic acid in the alloxan-diabetic rat.

Authors: R R Brenner; R O Peluffo; O Mercuri; M A Restelli
Journal: Am J Physiol Date: 1968-07

4. Effect of diet on linoleic acid desaturation and on some enzymes of carbohydrate metabolism.

Authors: I N De Gomez Dumm; M J De Alaniz; R R Brenner
Journal: J Lipid Res Date: 1970-03 Impact factor: 5.922

5. The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver.

Authors: N Oshino; R Sato
Journal: Arch Biochem Biophys Date: 1972-04 Impact factor: 4.013

6. RNA biosynthesis in adipose tissue: effect of fasting.

Authors: W Benjamin; A Gellhorn
Journal: J Lipid Res Date: 1966-03 Impact factor: 5.922

7. KINETICS OF LINOLEIC AND ARACHIDONIC ACID INCORPORATION AND EICOSATRIENOIC DEPLETION IN THE LIPIDS OF FAT-DEFICIENT RATS FED METHYL LINOLEATE AND ARACHIDONATE.

Authors: R R BRENNER; A M NERVI
Journal: J Lipid Res Date: 1965-07 Impact factor: 5.922

8. Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of alpha-linolenic acid family in culture of minimal deviation hepatoma 7288 C cells.

Authors: M J de Alaniz; R R Brenner
Journal: Mol Cell Biochem Date: 1976-08-30 Impact factor: 3.396

9. Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

Authors: R R Brenner; R O Peluffo
Journal: J Biol Chem Date: 1966-11-25 Impact factor: 5.157

10. Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions.

Authors: J C Castuma; A Catala; R R Brenner
Journal: J Lipid Res Date: 1972-11 Impact factor: 5.922

9 in total

Effect of fasting on delta 5 desaturation activity in rat liver microsomes and HTC cells.

1. UPTAKE OF FREE FATTY ACIDS BY EHRLICH ASCITES TUMOR CELLS.

2. Specificity of 5- and 6-fatty acid desaturases in rat and fish.

3. Effect of arachidonic acid in the alloxan-diabetic rat.

4. Effect of diet on linoleic acid desaturation and on some enzymes of carbohydrate metabolism.

5. The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver.

6. RNA biosynthesis in adipose tissue: effect of fasting.

7. KINETICS OF LINOLEIC AND ARACHIDONIC ACID INCORPORATION AND EICOSATRIENOIC DEPLETION IN THE LIPIDS OF FAT-DEFICIENT RATS FED METHYL LINOLEATE AND ARACHIDONATE.

8. Effect of different carbon sources on the biosynthesis of polyunsaturated fatty acids of alpha-linolenic acid family in culture of minimal deviation hepatoma 7288 C cells.

9. Effect of saturated and unsaturated fatty acids on the desaturation in vitro of palmitic, stearic, oleic, linoleic, and linolenic acids.

10. Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions.

1. Dexamethasone blocks arachidonate biosynthesis in isolated hepatocytes and cultured hepatoma cells.

2. Desaturation and chain elongation of essential fatty acids in isolated liver cells from rat and rainbow trout.

3. Effect of different carbon sources on delta 5 desaturation activity of HTC cells.

4. Metabolism of n-3 and n-6 fatty acids in Atlantic salmon liver: stimulation by essential fatty acid deficiency.

5. Eicosapentaenoic acid inhibits cell growth and triacylglycerol secretion in McA-RH7777 rat hepatoma cultures.

6. Effect of fatty acids of omega 6 series on the biosynthesis of arachidonic acid in HTC cells.

7. ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.

8. Role of fatty acids of (n-3) and (n-6) series on alpha-linolenic acid desaturation and chain elongation in HTC cells.

9. Uptake and metabolism of eicosa-8, 11, 14-trienoic acid in normal hepatocytes and HTC cells.