| Literature DB >> 7461909 |
O Cascone, M J Biscoglio de Jimenez Bonino, J A Santomé.
Abstract
The methionine residues in bovine growth hormone were chemically modified wih chloramine-T at pH 7.4 using different chloramine-T methionine molar ratios. Methionine 4 was shown to be the most reactive followed in decreasing order by methionines 148, 123 and 178. With a 50-fold molar excess of chloramine-T over methionine almost full oxidation of all the methionine residues was achieved. The oxidation of the four residues of methionine does not change the growth promoting activity of the hormone.Entities:
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Year: 1980 PMID： 7461909 DOI： 10.1111/j.1399-3011.1980.tb02590.x
Source DB: PubMed Journal: Int J Pept Protein Res ISSN： 0367-8377