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Literature DB >> 7461726

The elimination of circulating complexes containing polymeric IgA by excretion in the bile.

J Peppard, E Orlans, A W Payne, E Andrew.

Abstract

Radiolabelled human dimeric IgA injected intravenously into rats behaved like oligomeric rat IgA in that 40% of the injected dose was recovered in the bile within 6 h. Monomeric IgA was not transported into bile. In addition, dimeric IgA was able to carry with it macromolecular material in the form of a complex that also included rat SC. This was demonstrated in rats which had received an intravenous injection of specifically purified radiolabelled rabbit antibody tao the idiotype of a human IgA myeloma: when a later injection of unlabelled IgA dimer with the corresponding idiotype was given up to 18% of the rabbit antibody when the monomeric form of the same IgA was injected. This mechanism for clearing complexes containing polymeric IgA is mediated by hepatocytes and is distinct from the phagocyte-mediated mechanisms which clear conventional complexes.

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Year: 1981 PMID： 7461726 PMCID： PMC1458204

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

13 in total

1. Interaction of rabbit secretory component with rabbit IgA dimer.

Authors: L C Kühn; J P Kraehenbuhl
Journal: J Biol Chem Date: 1979-11-10 Impact factor: 5.157

2. Occurrence of specific antibodies of the IgA class in the bile of rats.

Authors: J Hall; E Orlans; J Reynolds; C Dean; J Peppard; L Gyure; S Hobbs
Journal: Int Arch Allergy Appl Immunol Date: 1979

3. The transport by hepatocytes of immunoglobulin A from blood to bile visualized by autoradiography and electron microscopy.

Authors: M S Birbeck; P Cartwright; J G Hall; E Orlans; J Peppard
Journal: Immunology Date: 1979-06 Impact factor: 7.397

4. Biliary transport of IgA: role of secretory component.

Authors: M M Fisher; B Nagy; H Bazin; B J Underdown
Journal: Proc Natl Acad Sci U S A Date: 1979-04 Impact factor: 11.205

5. Studies on the lymphocytes of sheep. III. Destination of lymph-borne immunoblasts in relation to their tissue of origin.

Authors: J G Hall; J Hopkins; E Orlans
Journal: Eur J Immunol Date: 1977-01 Impact factor: 5.532

6. Glutaraldehyde-activated aminohexyl- derivative of Sepharose 4B as a new verstile immunoabsorbent.

Authors: C L Cambiaso; A Goffinet; J P Vaerman; J F Heremans
Journal: Immunochemistry Date: 1975-04

7. Mesenteric lymph as a major source of serum IgA in guinea pigs and rats.

Authors: J P Vaerman; C André; H Bazin; J F Heremans
Journal: Eur J Immunol Date: 1973-09 Impact factor: 5.532

8. Effect of a disulfide-interchange enzyme on the assembly of human secretory immunoglobulin A from immunoglobulin A and free secretory component.

Authors: N A Murkofsky; M E Lamm
Journal: J Biol Chem Date: 1979-12-10 Impact factor: 5.157

9. Rapid active transport of immunoglobulin A from blood to bile.

Authors: E Orlans; J Peppard; J Reynolds; J Hall
Journal: J Exp Med Date: 1978-02-01 Impact factor: 14.307

10. Identification of secretory component as an IgA receptor on rat hepatocytes.

Authors: D J Socken; K N Jeejeebhoy; H Bazin; B J Underdown
Journal: J Exp Med Date: 1979-12-01 Impact factor: 14.307

22 in total

1. Epithelial cell polarization is a determinant in the infectious outcome of immunoglobulin A-mediated entry by Epstein-Barr virus.

Authors: Y J Gan; J Chodosh; A Morgan; J W Sixbey
Journal: J Virol Date: 1997-01 Impact factor: 5.103

Review 2. Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases.

Authors: M Kilian; J Mestecky; M W Russell
Journal: Microbiol Rev Date: 1988-06

3. Clearance kinetics and tissue distribution of aggregated human serum IgA in rats.

Authors: W M Bogers; A Gorter; M E Stuurman; L A Van Es; M R Daha
Journal: Immunology Date: 1989-06 Impact factor: 7.397

4. Comparative studies on immunoglobulins, complement component (C3), albumin, and immunoglobulin A-containing circulating immune complexes in serum and bile of patients with biliary obstruction.

Authors: G Ohshio; F Furukawa; T Manabe; T Tobe; Y Hamashima
Journal: Dig Dis Sci Date: 1988-05 Impact factor: 3.199

5. Experimental cholestasis promotes the deposition of glomerular IgA immune complexes.

Authors: S N Emancipator; G R Gallo; R Razaboni; M E Lamm
Journal: Am J Pathol Date: 1983-10 Impact factor: 4.307

6. [Alcohol and IgA in the kidney].

Authors: H Köhler
Journal: Klin Wochenschr Date: 1985-09-16

Review 7. Antigen processing and uptake from the intestinal tract.

Authors: R E Kleinman; W A Walker
Journal: Clin Rev Allergy Date: 1984-02

8. The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.

Authors: C S Kaetzel; J K Robinson; K R Chintalacharuvu; J P Vaerman; M E Lamm
Journal: Proc Natl Acad Sci U S A Date: 1991-10-01 Impact factor: 11.205

9. Immunoglobulin A-mediated hepatobiliary transport constitutes a natural pathway for disposing of bacterial antigens.

Authors: M W Russell; T A Brown; J L Claflin; K Schroer; J Mestecky
Journal: Infect Immun Date: 1983-12 Impact factor: 3.441

10. Selective transport of polymeric immunoglobulin A in bile. Quantitative relationships of monomeric and polymeric immunoglobulin A, immunoglobulin M, and other proteins in serum, bile, and saliva.

Authors: D L Delacroix; H J Hodgson; A McPherson; C Dive; J P Vaerman
Journal: J Clin Invest Date: 1982-08 Impact factor: 14.808