| Literature DB >> 7460833 |
U Weinberg, F J Gasparini, E D Weitzman.
Abstract
The developmental pattern of the in vitro rat liver melatonin degrading activity was studied. Livers from rats 3, 12, 16, 21, 30 and 90 days old were incubated with [3H] melatonin. A high pressure liquid chromatography (HPLC) technique was used to determine the appearance of melatonin metabolic product--6-hydroxymelatonin--in the liver extract. Catabolic activity belong very low at age 3 days, increased rapidly with age and reached maximum activity between the ages 21 to 30 days.Entities:
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Year: 1981 PMID： 7460833 DOI： 10.1210/endo-108-3-1081
Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736