Literature DB >> 7460070

Binding of chemical carcinogens and mutagens to rat hemoglobin.

M A Pereira, L W Chang.   

Abstract

The alkylation of hemoglobin is a proposed dose monitor for chemical carcinogens and mutagens. The binding of fifteen chemical carcinogens and mutagens to rat hemoglobin was determined. Direct acting carcinogens and indirect acting carcinogens including aromatic amines, halogenated hydrocarbons, nitrosamines, polycyclic aromatic hydrocarbons, aflatoxin B1 and benzene bound hemoglobin. The efficiency of carcinogen and mutagen hemoglobin was dose dependent and ranged from 0.007 to 2.3% of an oral dose. The binding of chemical carcinogens and mutagens to hemoglobin would appear to be generic so that it could be developed into a dose monitor for a large number of known carcinogens and mutagens.

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Year:  1981        PMID： 7460070     DOI： 10.1016/0009-2797(81)90048-x

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  13 in total

Review 1.  The use of biomonitoring data in exposure and human health risk assessment: benzene case study.

Authors:  Scott M Arnold; Juergen Angerer; Peter J Boogaard; Michael F Hughes; Raegan B O'Lone; Steven H Robison; A Robert Schnatter
Journal:  Crit Rev Toxicol       Date:  2013-02       Impact factor: 5.635

2.  Biomonitoring of aromatic amines and alkylating agents by measuring hemoglobin adducts.

Authors:  H G Neumann
Journal:  Int Arch Occup Environ Health       Date:  1988       Impact factor: 3.015

Review 3.  Estimation of exposure of man to substances reacting covalently with macromolecules.

Authors:  P B Farmer; H G Neumann; D Henschler
Journal:  Arch Toxicol       Date:  1987-06       Impact factor: 5.153

4.  S-phenylcysteine formation in hemoglobin as a biological exposure index to benzene.

Authors:  W E Bechtold; J D Sun; L S Birnbaum; S N Yin; G L Li; S Kasicki; G Lucier; R F Henderson
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

5.  Biological monitoring of acrylonitrile exposure through a new analytical approach to hemoglobin and plasma protein adducts and urinary metabolites in rats and humans.

Authors:  V Ivanov; K Hashimoto; K Inomata; T Kawai; K Mizunuma; L Klimatskaya
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

6.  Development of an immunoassay to detect hemoglobin adducts formed by benzene exposure.

Authors:  J Grassman; R Haas
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

7.  Benzo(a)pyrene-blood protein adducts in wild woodchucks used as biological sentinels of environmental polycyclic aromatic hydrocarbons contamination.

Authors:  O Blondin; C Viau
Journal:  Arch Environ Contam Toxicol       Date:  1992-10       Impact factor: 2.804

8.  Alteration of biogenic amines in mouse brain regions by alkylating agents. I. Effects of aflatoxin B1 on brain monoamines concentrations and activities of metabolizing enzymes.

Authors:  S Jayasekara; D B Drown; R A Coulombe; R P Sharma
Journal:  Arch Environ Contam Toxicol       Date:  1989 May-Jun       Impact factor: 2.804

9.  Binding characteristics of ortho-toluidine to rat hemoglobin and albumin.

Authors:  D G DeBord; T F Swearengin; K L Cheever; A D Booth-Jones; L A Wissinger
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

10.  Analysis of hemoglobin as a dose monitor for alkylating and arylating agents.

Authors:  H G Neumann
Journal:  Arch Toxicol       Date:  1984-11       Impact factor: 5.153
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