Literature DB >> 7459706

Ethnic difference in drug metabolism: debrisoquine 4-hydroxylation in Caucasians and Orientals.

W Kalow, S V Otton, D Kadar, L Endrenyi, T Inaba.   

Abstract

The extent to which debrisoquine (D) is metabolized to 4-hydroxydebrisoquine (4OHD) was found to be influenced by the ethnic origin of the subjects. Following ingestion of 20 mg of debrisoquine sulfate, Orientals excreted, on the average, significantly more D and less 4OHD in 0- to 8-h urine than Caucasians; however, the sums of D + 4OHD did not differ.

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Year:  1980        PMID: 7459706     DOI: 10.1139/y80-173

Source DB:  PubMed          Journal:  Can J Physiol Pharmacol        ISSN: 0008-4212            Impact factor:   2.273


  11 in total

Review 1.  Ethnic differences in drug disposition and responsiveness.

Authors:  A J Wood; H H Zhou
Journal:  Clin Pharmacokinet       Date:  1991-05       Impact factor: 6.447

Review 2.  Pharmacogenetics and ecogenetics.

Authors:  D P Agarwal; H W Goedde
Journal:  Experientia       Date:  1986-10-15

Review 3.  Ethnic differences in drug metabolism.

Authors:  W Kalow
Journal:  Clin Pharmacokinet       Date:  1982 Sep-Oct       Impact factor: 6.447

4.  Unimodal distribution of the metabolic ratio for debrisoquine in Cuna Amerindians of Panama.

Authors:  L F Jorge; T D Arias; T Inaba; P R Jackson
Journal:  Br J Clin Pharmacol       Date:  1990-08       Impact factor: 4.335

5.  Human pharmacogenomics: the development of a science.

Authors:  Werner Kalow
Journal:  Hum Genomics       Date:  2004-08       Impact factor: 4.639

6.  Desipramine pharmacokinetics in Chinese and Caucasian volunteers.

Authors:  M V Rudorfer; E A Lane; W H Chang; M D Zhang; W Z Potter
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

7.  A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine.

Authors:  Q Y Yue; J O Svensson; F Sjöqvist; J Säwe
Journal:  Br J Clin Pharmacol       Date:  1991-06       Impact factor: 4.335

8.  Genetic polymorphism of mephenytoin p(4')-hydroxylation: difference between Orientals and Caucasians.

Authors:  M Jurima; T Inaba; D Kadar; W Kalow
Journal:  Br J Clin Pharmacol       Date:  1985-04       Impact factor: 4.335

9.  Evidence for the polymorphic oxidation of debrisoquine in the Thai population.

Authors:  S Wanwimolruk; P Patamasucon; E J Lee
Journal:  Br J Clin Pharmacol       Date:  1990-02       Impact factor: 4.335

10.  Paroxetine versus Venlafaxine and Escitalopram in Korean Patients with Major Depressive Disorder: A Randomized, Rater-blinded, Six-week Study.

Authors:  Young Sup Woo; Roger S McIntyre; Jung-Bum Kim; Min-Soo Lee; Jae-Min Kim; Hyeon Woo Yim; Tae-Youn Jun
Journal:  Clin Psychopharmacol Neurosci       Date:  2017-11-30       Impact factor: 2.582

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