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Literature DB >> 7459206

Survival of intestinal crypts after treatment by adriamycin alone or with radiation.

Abstract

A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) compared to the value for gamma radiation. This observation is discussed with respect to the interpretation of crypt survival curves. We were unable to demonstrate any enhancement by adriamycin (reduction in Dq) of the response of microcolony-forming cells to radiation given immediately before the drug.

Entities: Chemical Species

Mesh：

Substances：
Doxorubicin

Year: 1980 PMID： 7459206 PMCID： PMC2010542 DOI： 10.1038/bjc.1980.303

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

13 in total

2. Interactions of radiation and adriamycin, bleomycin, mitomycin C or cis-diamminedichloroplatinum II in intestinal crypt cells.

Authors: H von der Maase
Journal: Br J Cancer Date: 1984-06 Impact factor: 7.640

2 in total

Survival of intestinal crypts after treatment by adriamycin alone or with radiation.

1. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.

2. The interaction between radiation and adriamycin damage in mammalian cells.

3. Letter: Effects of adriamycin on the radiation response of murine hematopoietic stem cells.

4. The effects of adriamycin on murine duodenal crypt cell proliferation.

5. Cryptogenic cells and proliferative cells in intestinal epithelium.

6. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation.

7. Computer programmes for fitting Puck and probit survival curves.

8. The effects of X-irradiation and adriamycin on proliferating and nonproliferating hair coat of the mouse.

9. Modification of radiation injury to normal tissues by chemotherapeutic agents.

10. Cell-survival characteristics of intestinal stem cells and crypts of gamm-irradiated mice.

1. Death of intestinal crypts and of their constituent cells after treatment by chemotherapeutic drugs.

2. Interactions of radiation and adriamycin, bleomycin, mitomycin C or cis-diamminedichloroplatinum II in intestinal crypt cells.