Literature DB >> 7458518

Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases.

B R Bacon, W H Treuhaft, A M Goodman.   

Abstract

Two patients became severely pancytopenic while receiving azathioprine in low dosages for treatment of connective-tissue diseases. While mild hematologic complications are common with this drug, we believe that the degree of bone marrow suppression exhibited in these two patients is unusual, especially at the dosages (0.75 and 1.25 mg/kg/day) of azathioprine being used.

Entities:  

Mesh:

Substances:

Year:  1981        PMID: 7458518

Source DB:  PubMed          Journal:  Arch Intern Med        ISSN: 0003-9926


  6 in total

Review 1.  Drug interactions that matter. A critical reappraisal.

Authors:  G T McInnes; M J Brodie
Journal:  Drugs       Date:  1988-07       Impact factor: 9.546

2.  Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.

Authors:  W R Connell; M A Kamm; J K Ritchie; J E Lennard-Jones
Journal:  Gut       Date:  1993-08       Impact factor: 23.059

3.  The haemotoxicity of azathioprine in repeat dose studies in the female CD-1 mouse.

Authors:  Gemma Molyneux; Frances M Gibson; Christabelle M Chen; Harpal K Marway; Sean McKeag; Charles V J Mifsud; Andrew M Pilling; Matthew J Whayman; John A Turton
Journal:  Int J Exp Pathol       Date:  2008-04       Impact factor: 1.925

4.  Azathioprine-induced pancytopenia with normal TPMT activity presenting with HSV oral ulcers.

Authors:  Caroline H Jensen; John Tiu; Jillian S Catalanotti
Journal:  BMJ Case Rep       Date:  2018-07-11

5.  Allopurinol influences aminophenazone elimination.

Authors:  M Barry; J Feely
Journal:  Clin Pharmacokinet       Date:  1990-08       Impact factor: 6.447

Review 6.  Pancytopenia related to azathioprine--an enzyme deficiency caused by a common genetic polymorphism: a review.

Authors:  A Anstey; L Lennard; S C Mayou; J D Kirby
Journal:  J R Soc Med       Date:  1992-12       Impact factor: 18.000

  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.