[The influence of radio- and chemotherapy on DNA repair of peripheral lymphocytes of tumor patients (author's transl)].

The influence of radiotherapy in 10 patients and chemotherapy in 5 patients, on DNA excision repair capacity was investigated in lymphocytes of the peripheral blood. No effects on DNA repair were found using only betatrone of 60Co-irradiation under normal conditions. Combination of both irradiation schedules over a longer period of therapy provoked an inhibition of DNA repair. Chemotherapy inhibits DNA repair immediately after starting therapy, but after a relatively short time, the extent of DNA repair increases above normal level.