Pathogenicity of some ordinarily harmless yeasts for cortisone-treated mice.

The pathogenicity for normal and cortisone-treated mice of Candida requinyii, Pichia etchellsii, Candida famata (Torulopsis candida) Trichosporon cutaneum and Sterigmatomyces aphidis, isolated from foodstuffs or clinical material, is reported. The test species proved nonpathogenic to normal mice inoculated intravenously with up to 10(7) cells. There was neither any mortality nor gross or microscopic lesions, and cultures were negative from the visceral organs and brain when these animals were necropsied after 3 weeks of observation. In cortisone-treated mice, on the other hand, the yeasts caused mortalities, the extent of which varied according to the infecting species and the challenge dose. Candida requinyii was the most pathogenic species, causing 100% mortality in 8 days, followed by S. aphidis, C. famata, T. cutaneum and P. etchellsii which killed 75%, 50%, 38% and 25% of the infected animals. Apart from the higher mortalities, C. requinyii and S. aphidis caused more frequent visceral lesions than did either T. cutaneum or C. famata. Involvement of the brain occurred more commonly with C. requinyii and T. cutaneum than with C. famata or S. aphidis. P. etchellsii was the only yeast that failed to incite any gross or microscopic lesions. The study re-emphasizes the pathogenic potential of ordinarily harmless fungi for immunosuppressed hosts.